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Müller PL, Treis T, Alsaedi A, et al. Foveal structure and visual function in nanophthalmos and posterior microphthalmos. Br J Ophthalmol. 2021;doi: 10.1136/bjophthalmol-2020-318717.
Müller, P. L., Treis, T., Alsaedi, A., Webster, A. R., Khaw, P., Michaelides, M., Wickham, L., Siriwardena, D., Foster, P., Moosajee, M., Pavesio, C., Tufail, A., & Egan, C. (2021). Foveal structure and visual function in nanophthalmos and posterior microphthalmos. The British journal of ophthalmology, . https://doi.org/10.1136/bjophthalmol-2020-318717
Müller, Philipp L, et al. "Foveal structure and visual function in nanophthalmos and posterior microphthalmos." The British journal of ophthalmology vol. (2021). doi: https://doi.org/10.1136/bjophthalmol-2020-318717
Müller PL, Treis T, Alsaedi A, Webster AR, Khaw P, Michaelides M, Wickham L, Siriwardena D, Foster P, Moosajee M, Pavesio C, Tufail A, Egan C. Foveal structure and visual function in nanophthalmos and posterior microphthalmos. Br J Ophthalmol. 2021 Jul 22; doi: 10.1136/bjophthalmol-2020-318717. Epub 2021 Jul 22. PMID: 34301612.
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Br J Ophthalmol. 2021 Jul 22; doi: 10.1136/bjophthalmol-2020-318717. Epub 2021 Jul 22.

Foveal structure and visual function in nanophthalmos and posterior microphthalmos.

The British journal of ophthalmology

Philipp L Müller, Tim Treis, Abdulrahman Alsaedi, Andrew R Webster, Peng Khaw, Michel Michaelides, Louisa Wickham, Dilani Siriwardena, Paul Foster, Mariya Moosajee, Carlos Pavesio, Adnan Tufail, Catherine Egan

Affiliations

  1. Moorfields Eye Hospital NHS Foundation Trust, London, UK.
  2. Department of Ophthalmology, University of Bonn, Bonn, Germany.
  3. Macula Center, Suedblick Eye Centers, Augsburg, Germany.
  4. Institute of Ophthalmology, University College London, London, UK.
  5. Institute of Pharmacy and Molekular Biotechnology, University of Heidelberg, Heidelberg, Germany.
  6. College of Medicine, Imam Muhammad bin Saud Islamic University, Riyadh, Saudi Arabia.
  7. Great Ormond Street Hospital for Children, London, UK.
  8. Moorfields Eye Hospital NHS Foundation Trust, London, UK [email protected].

PMID: 34301612 DOI: 10.1136/bjophthalmol-2020-318717

Abstract

BACKGROUND/AIMS: The reason for visual impairment in patients with nanophthalmos and posterior microphthalmos is not completely understood. Therefore, this study aims to investigate foveal structure, and the impact of demographic, clinical and imaging parameters on best-corrected visual acuity (BCVA) in these conditions.

METHODS: Sixty-two eyes of 33 patients with nanophthalmos (n=40) or posterior microphthalmos (n=22), and 114 eyes of healthy controls with high-resolution retinal imaging including spectral-domain or swept-source optical coherence tomography images were included in this cross-sectional case-control study. Foveal retinal layer thickness was determined by two independent readers. A mixed-effect model was used to perform structure-function correlations and predict the BCVA based on subject-specific variables.

RESULTS: Most patients (28/33) had altered foveal structure associated with loss of foveal avascular zone and impaired BCVA. However, widening of outer nuclear layer, lengthening of photoreceptor outer segments, normal distribution of macular pigment and presence of Henle fibres were consistently found. Apart from the presence of choroidal effusion, which had significant impact on BCVA, the features age, refractive error, axial length and retinal layer thickness at the foveal centre explained 61.7% of the variability of BCVA.

CONCLUSION: This study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities.

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: imaging; macula; retina

Conflict of interest statement

Competing interests: None declared.

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