Display options
Cite
Kudinov VA, Torkhovskaya TI, Zakharova TS, et al. High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis. Biomed Pharmacother. 2021;141:111900doi: 10.1016/j.biopha.2021.111900.
Kudinov, V. A., Torkhovskaya, T. I., Zakharova, T. S., Morozevich, G. E., Artyushev, R. I., Zubareva, M. Y., & Markin, S. S. (2021). High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 141111900. https://doi.org/10.1016/j.biopha.2021.111900
Kudinov, Vasily A, et al. "High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 141 (2021): 111900. doi: https://doi.org/10.1016/j.biopha.2021.111900
Kudinov VA, Torkhovskaya TI, Zakharova TS, Morozevich GE, Artyushev RI, Zubareva MY, Markin SS. High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis. Biomed Pharmacother. 2021 Sep;141:111900. doi: 10.1016/j.biopha.2021.111900. Epub 2021 Jul 13. PMID: 34328100.
Copy Download .nbib Format: NLM
Share it on

Biomed Pharmacother. 2021 Sep;141:111900. doi: 10.1016/j.biopha.2021.111900. Epub 2021 Jul 13.

High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Vasily A Kudinov, Tatiana I Torkhovskaya, Tamara S Zakharova, Galina E Morozevich, Rafael I Artyushev, Marina Yu Zubareva, Sergey S Markin

Affiliations

  1. Scientific Group of Phospholipid Drugs, Institute of Biomedical Chemistry, 119121 Moscow, Russia; Laboratory of Cell Biology and Developmental Pathology, FSBSI Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia. Electronic address: [email protected].
  2. Laboratory of Phospholipid Transport Systems and Nanomedicines, Institute of Biomedical Chemistry, 119121 Moscow, Russia. Electronic address: [email protected].
  3. Laboratory of Phospholipid Transport Systems and Nanomedicines, Institute of Biomedical Chemistry, 119121 Moscow, Russia. Electronic address: [email protected].
  4. Laboratory of Protein Biosynthesis, Institute of Biomedical Chemistry, 119121 Moscow, Russia. Electronic address: [email protected].
  5. Scientific Group of Phospholipid Drugs, Institute of Biomedical Chemistry, 119121 Moscow, Russia. Electronic address: [email protected].
  6. Department of Atherosclerosis Problems, FSBI National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation, Moscow, Russia. Electronic address: [email protected].
  7. Clinical Research Department, Institute of Biomedical Chemistry, 119121 Moscow, Russia. Electronic address: [email protected].

PMID: 34328100 DOI: 10.1016/j.biopha.2021.111900

Abstract

The efficiency of cholesterol efflux from cells promoted by high-density lipoproteins (HDLs) depends on HDL concentration and functional properties. The term "dysfunctional HDL" describes HDLs with impaired protective properties. Cholesterol efflux capacity (CEC) of HDL is reduced in patients with atherosclerosis, but the exact mechanisms underlying this impairment are not well characterized. Enriching HDLs with phospholipids (PLs) improves CEC. Herein, we assessed the potential of PL nanoparticles in improving HDL functionality. We lipidated HDL subfractions by incubating with PL nanoparticles containing soybean polyunsaturated phosphatidylcholine. Incubating blood plasma with PL nanoparticles resulted in the dose-dependent lipidation of all HDL subfractions. Changes in apolipoprotein A1 (apoA-1) and PL concentrations were the most prominent in the HDL

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Keywords: Atorvastatin; Cholesterol; Dyslipidemia; Macrophage; Phosphatidylcholine; Reverse cholesterol transport

Publication Types