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McGrath M, Hoyt H, Pence A, et al. Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. Br J Pharmacol. 2021;178(24):4842-4858doi: 10.1111/bph.15662.
McGrath, M., Hoyt, H., Pence, A., Forman, S. A., & Raines, D. E. (2021). Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. British journal of pharmacology, 178(24), 4842-4858. https://doi.org/10.1111/bph.15662
McGrath, Megan, et al. "Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA." British journal of pharmacology vol. 178,24 (2021): 4842-4858. doi: https://doi.org/10.1111/bph.15662
McGrath M, Hoyt H, Pence A, Forman SA, Raines DE. Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. Br J Pharmacol. 2021 Dec;178(24):4842-4858. doi: 10.1111/bph.15662. Epub 2021 Sep 26. PMID: 34386973; PMCID: PMC8637433.
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Br J Pharmacol. 2021 Dec;178(24):4842-4858. doi: 10.1111/bph.15662. Epub 2021 Sep 26.

Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA.

British journal of pharmacology

Megan McGrath, Helen Hoyt, Andrea Pence, Stuart A Forman, Douglas E Raines

Affiliations

  1. Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

PMID: 34386973 PMCID: PMC8637433 DOI: 10.1111/bph.15662

Abstract

BACKGROUND AND PURPOSE: In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABA

EXPERIMENTAL APPROACH: With flumazenil blocking classical high-affinity extracellular benzodiazepine site effects, modulation of GABA-activated currents by diazepam, midazolam and flurazepam was measured electrophysiologically in wildtype and M2-15' mutant α

KEY RESULTS: In the presence of flumazenil, micromolar concentrations of diazepam and midazolam both potentiated and inhibited wildtype GABA

CONCLUSIONS AND IMPLICATIONS: Benzodiazepine binding to transmembrane anaesthetic binding sites of the GABA

© 2021 The British Pharmacological Society.

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