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Severcan EU, Bal CM, Tanac R, et al. Retrospektive Querschnittsanalyse von mit Asthma assoziierten Faktoren in einer pädiatrischen Kohorte aus der Türkei. Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey. Klin Padiatr. 2021;doi: 10.1055/a-1500-8264.
Severcan, E. U., Bal, C. M., Tanac, R., Gulen, F., & Demir, E. (2021). Retrospektive Querschnittsanalyse von mit Asthma assoziierten Faktoren in einer pädiatrischen Kohorte aus der Türkei. Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey. Klinische Padiatrie, . https://doi.org/10.1055/a-1500-8264
Severcan, Ezgi Ulusoy, et al. "Retrospektive Querschnittsanalyse von mit Asthma assoziierten Faktoren in einer pädiatrischen Kohorte aus der Türkei." Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey. Klinische Padiatrie vol. (2021). doi: https://doi.org/10.1055/a-1500-8264
Severcan EU, Bal CM, Tanac R, Gulen F, Demir E. Retrospektive Querschnittsanalyse von mit Asthma assoziierten Faktoren in einer pädiatrischen Kohorte aus der Türkei. Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey. Klin Padiatr. 2021 Jul 30; doi: 10.1055/a-1500-8264. Epub 2021 Jul 30. PMID: 34331302.
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Klin Padiatr. 2021 Jul 30; doi: 10.1055/a-1500-8264. Epub 2021 Jul 30.

Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey.

Klinische Padiatrie

Ezgi Ulusoy Severcan, Cem Murat Bal, Remziye Tanac, Figen Gulen, Esen Demir

Affiliations

  1. Department of Pediatric Immunology and Allergy, Ege University Faculty of Medicine, Izmir, Turkey.
  2. Department of Pediatric Pulmonology, Ege University Faculty of Medicine, Izmir, Turkey.

PMID: 34331302 DOI: 10.1055/a-1500-8264

Abstract

BACKGROUND: It is difficult to identify young children at increased risk of developing asthma amongst those with recurrent wheezing. In this study, we aimed to determine factors associated with asthma in Turkish children.

METHODS: We performed a retrospective cross-sectional analysis on factors associated with asthma in 651 children (200 girls, 451 boys) admitted for recurrent wheezing.

RESULTS: Amongst all included children, asthma frequency was 57.7%. Maturity, consanguinity, family income, passive smoking, father's, siblings' asthma were not found to be associated with asthma. Factors associated with asthma were: family's, parents', siblings' atopy, family's, mother's asthma, allergic rhinitis and atopic dermatitis, respiratory symptoms between wheezing attacks. The sensitivity (SN) of the modified asthma predictive index (mAPI) was 59.2% with a specificity (SP) of 91.3%, positive predictive index (PPI) of 65.1% and negative predictive index (NPI) of 82.3%. The SN of the modified Prevention and Incidence of Asthma and Mite Allergy (PIAMA) score was 22.9% with a SP of 89.2%, PPI of 84.6%, and NPI of 42.2%. Adjusted odds ratio for mAPI was 12.9, and for the modified PIAMA score 4.

CONCLUSION: Our analysis confirmed previously described factors associated with asthma. Although the SN is limited, the mAPI and PIAMA risk scores can be used to predict asthma in Turkish children. Differential diagnoses and overlaps with other chronic pediatric diseases such as immunodeficiencies need to be carefully excluded when confirming the diagnosis asthma.

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Conflict of interest statement

The Authors declare that they have no conflict of interest.

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