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Gordon SR, Reaume DR, Perkins TR. Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue. Growth Factors. 2021;38(5):269-281doi: 10.1080/08977194.2021.1963721.
Gordon, S. R., Reaume, D. R., & Perkins, T. R. (2020). Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue. Growth factors (Chur, Switzerland), 38(5), 269-281. https://doi.org/10.1080/08977194.2021.1963721
Gordon, Sheldon R, et al. "Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue." Growth factors (Chur, Switzerland) vol. 38,5 (2020): 269-281. doi: https://doi.org/10.1080/08977194.2021.1963721
Gordon SR, Reaume DR, Perkins TR. Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue. Growth Factors. 2020 Dec;38(5):269-281. doi: 10.1080/08977194.2021.1963721. Epub 2021 Aug 13. PMID: 34388064.
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Growth Factors. 2020 Dec;38(5):269-281. doi: 10.1080/08977194.2021.1963721. Epub 2021 Aug 13.

Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue.

Growth factors (Chur, Switzerland)

Sheldon R Gordon, Darryl R Reaume, Thomas R Perkins

Affiliations

  1. Department of Biological Sciences, Oakland University, Rochester, MI, USA.

PMID: 34388064 DOI: 10.1080/08977194.2021.1963721

Abstract

The ability of insulin and IGF-2 to support wound repair in the organ-cultured rat corneal endothelium was investigated. Corneas given a circular transcorneal freeze injury, were explanted into organ cultures containing either insulin or IGF-2 and cultured up to72 h. Both factors increased [

Keywords: Corneal endothelium; DNA synthesis; IGF-2; insulin; mitosis; organ culture; protein kinase C; wound closure

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