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You K, Gu H, Yuan Z, et al. Tumor Necrosis Factor Alpha Signaling and Organogenesis. Front Cell Dev Biol. 2021;9:727075doi: 10.3389/fcell.2021.727075.
You, K., Gu, H., Yuan, Z., & Xu, X. (2021). Tumor Necrosis Factor Alpha Signaling and Organogenesis. Frontiers in cell and developmental biology, 9727075. https://doi.org/10.3389/fcell.2021.727075
You, Kai, et al. "Tumor Necrosis Factor Alpha Signaling and Organogenesis." Frontiers in cell and developmental biology vol. 9 (2021): 727075. doi: https://doi.org/10.3389/fcell.2021.727075
You K, Gu H, Yuan Z, Xu X. Tumor Necrosis Factor Alpha Signaling and Organogenesis. Front Cell Dev Biol. 2021 Jul 30;9:727075. doi: 10.3389/fcell.2021.727075. eCollection 2021. PMID: 34395451; PMCID: PMC8361451.
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Front Cell Dev Biol. 2021 Jul 30;9:727075. doi: 10.3389/fcell.2021.727075. eCollection 2021.

Tumor Necrosis Factor Alpha Signaling and Organogenesis.

Frontiers in cell and developmental biology

Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu

Affiliations

  1. Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
  2. Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, China.
  3. Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

PMID: 34395451 PMCID: PMC8361451 DOI: 10.3389/fcell.2021.727075

Abstract

Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication. TNF-α and its receptors are ubiquitously expressed in developing organs and they regulate the survival, proliferation, and apoptosis of embryonic stem cells (ESCs) and progenitor cells. TNF-α is an important inflammatory factor that also regulates the inflammatory response during organogenesis, and its cytotoxic effects can interfere with normal developmental processes, even leading to the onset of diseases. This review summarizes the various roles of TNF-α in organogenesis in terms of its secreting pattern, concentration-dependent activities, and interactions with other signaling pathways. We also explored new potential functions of TNF-α.

Copyright © 2021 You, Gu, Yuan and Xu.

Keywords: cell communication; development; morphogenesis; organogenesis; tumor necrosis factor alpha

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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