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Ijomone OM, Iroegbu JD, Aschner M, et al. Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system. Neurotoxicology. 2021;86:166-171doi: 10.1016/j.neuro.2021.08.005.
Ijomone, O. M., Iroegbu, J. D., Aschner, M., & Bornhorst, J. (2021). Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system. Neurotoxicology, 86166-171. https://doi.org/10.1016/j.neuro.2021.08.005
Ijomone, Omamuyovwi M, et al. "Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system." Neurotoxicology vol. 86 (2021): 166-171. doi: https://doi.org/10.1016/j.neuro.2021.08.005
Ijomone OM, Iroegbu JD, Aschner M, Bornhorst J. Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system. Neurotoxicology. 2021 Sep;86:166-171. doi: 10.1016/j.neuro.2021.08.005. Epub 2021 Aug 10. PMID: 34389354; PMCID: PMC8440482.
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Neurotoxicology. 2021 Sep;86:166-171. doi: 10.1016/j.neuro.2021.08.005. Epub 2021 Aug 10.

Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system.

Neurotoxicology

Omamuyovwi M Ijomone, Joy D Iroegbu, Michael Aschner, Julia Bornhorst

Affiliations

  1. Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany; The Neuro- Lab, Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure, Nigeria. Electronic address: [email protected].
  2. The Neuro- Lab, Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure, Nigeria.
  3. Departments of Molecular Pharmacology and Neurosciences, Albert Einstein College of Medicine, NY, USA.
  4. Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany.

PMID: 34389354 PMCID: PMC8440482 DOI: 10.1016/j.neuro.2021.08.005

Abstract

There are several candidate signalling pathways that mediate the response of the central nervous system (CNS) cells to environmental toxins. However, much is still to be learned on how these pathways modulate neurotoxicity. The mitogen-activated protein kinases (MAPKs) signalling pathways, which include the extracellular signal-regulated protein kinase (ERK) and the p38-MAPK, are potentially key pathways to regulate CNS responses to environmental toxins. The pathways play leading roles in the transmission of extracellular signals into the cell nucleus, leading to cell differentiation, cell growth, and apoptosis, to name a few. Moreover, exposure to environmental toxins induces p38- and ERK-MAPK activation, which leads to oxidative stress, inflammation, and apoptosis in the CNS. Here, we provide a concise review of the recent evidence demonstrating the role of p38- and ERK-MAPK signaling pathways and their downstream targets in the CNS following exposure to environmental toxicants such as metals, organophosphorus and persistent organic pollutants.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: CNS; MAPK signalling; Metals; Organophosphorus; Persistent organic pollutants

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