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Ooms JF, Bouwmeester S, Debonnaire P, et al. Transcatheter Edge-to-Edge Repair in Proportionate Versus Disproportionate Functional Mitral Regurgitation. J Am Soc Echocardiogr. 2021;doi: 10.1016/j.echo.2021.08.002.
Ooms, J. F., Bouwmeester, S., Debonnaire, P., Nasser, R., Voigt, J. U., Schotborgh, M. A., Geleijnse, M. L., Kardys, I., Spitzer, E., Daemen, J., De Jaegere, P. P., Houthuizen, P., Swaans, M. J., Dubois, C., Claeys, M., Van Der Heyden, J., Tonino, P. A., & Van Mieghem, N. M. (2021). Transcatheter Edge-to-Edge Repair in Proportionate Versus Disproportionate Functional Mitral Regurgitation. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, . https://doi.org/10.1016/j.echo.2021.08.002
Ooms, Joris F, et al. "Transcatheter Edge-to-Edge Repair in Proportionate Versus Disproportionate Functional Mitral Regurgitation." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography vol. (2021). doi: https://doi.org/10.1016/j.echo.2021.08.002
Ooms JF, Bouwmeester S, Debonnaire P, Nasser R, Voigt JU, Schotborgh MA, Geleijnse ML, Kardys I, Spitzer E, Daemen J, De Jaegere PP, Houthuizen P, Swaans MJ, Dubois C, Claeys M, Van Der Heyden J, Tonino PA, Van Mieghem NM. Transcatheter Edge-to-Edge Repair in Proportionate Versus Disproportionate Functional Mitral Regurgitation. J Am Soc Echocardiogr. 2021 Aug 11; doi: 10.1016/j.echo.2021.08.002. Epub 2021 Aug 11. PMID: 34389469.
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J Am Soc Echocardiogr. 2021 Aug 11; doi: 10.1016/j.echo.2021.08.002. Epub 2021 Aug 11.

Transcatheter Edge-to-Edge Repair in Proportionate Versus Disproportionate Functional Mitral Regurgitation.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Joris F Ooms, Sjoerd Bouwmeester, Philippe Debonnaire, Riwa Nasser, Jens-Uwe Voigt, Mark A Schotborgh, Marcel L Geleijnse, Isabella Kardys, Ernest Spitzer, Joost Daemen, Peter P De Jaegere, Patrick Houthuizen, Martin J Swaans, Christophe Dubois, Marc Claeys, Jan Van Der Heyden, Pim A Tonino, Nicolas M Van Mieghem

Affiliations

  1. Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.
  2. Catharina Hospital, Eindhoven, the Netherlands.
  3. Sint-Jan Hospital, Bruges, Belgium.
  4. University Hospital Antwerp, Antwerp, Belgium.
  5. University Hospital Leuven, Leuven, Belgium.
  6. St. Antonius Hospital, Nieuwegein, the Netherlands.
  7. Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: [email protected].

PMID: 34389469 DOI: 10.1016/j.echo.2021.08.002

Abstract

BACKGROUND: Functional mitral regurgitation (FMR) can be subclassified on the basis of its proportionality relative to left ventricular (LV) volume and function, indicating potential differences in underlying etiology. The aim of this study was to evaluate the association of FMR proportionality with FMR reduction, heart failure hospitalization and mortality after transcatheter edge-to-edge mitral valve repair (TEER).

METHODS: This multicenter registry included 241 patients with symptomatic heart failure with reduced LV ejection fraction treated with TEER for moderate to severe or greater FMR. FMR proportionality was graded on preprocedural transthoracic echocardiography using the ratio of the effective regurgitant orifice area to LV end-diastolic volume. Baseline characteristics, follow-up transthoracic echocardiography, and 2-year clinical outcomes were compared between groups.

RESULTS: Median LV ejection fraction, effective regurgitant orifice area and LV end-diastolic volume index were 30% (interquartile range [IQR], 25%-35%), 27 mm

CONCLUSIONS: TEER resulted in more pronounced early FMR reduction in patients with dFMR compared with those with pFMR. Yet after initial improvement, FMR deteriorated in a substantial number of patients, calling into question durable mitral regurgitation reductions with TEER in selected patients. The proportionality framework may not identify durable TEER responders.

Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

Keywords: Edge-to-edge mitral valve repair; Functional mitral regurgitation; Heart failure

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