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Tuohinen SS, Skyttä T, Huhtala H, et al. 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography. JACC CardioOncol. 2021;3(2):277-289doi: 10.1016/j.jaccao.2021.03.005.
Tuohinen, S. S., Skyttä, T., Huhtala, H., Poutanen, T., Virtanen, V., Kellokumpu-Lehtinen, P. L., & Raatikainen, P. (2021). 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography. JACC. CardioOncology, 3(2), 277-289. https://doi.org/10.1016/j.jaccao.2021.03.005
Tuohinen, Suvi Sirkku, et al. "3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography." JACC. CardioOncology vol. 3,2 (2021): 277-289. doi: https://doi.org/10.1016/j.jaccao.2021.03.005
Tuohinen SS, Skyttä T, Huhtala H, Poutanen T, Virtanen V, Kellokumpu-Lehtinen PL, Raatikainen P. 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography. JACC CardioOncol. 2021 Jun 15;3(2):277-289. doi: 10.1016/j.jaccao.2021.03.005. eCollection 2021 Jun. PMID: 34396335; PMCID: PMC8352342.
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JACC CardioOncol. 2021 Jun 15;3(2):277-289. doi: 10.1016/j.jaccao.2021.03.005. eCollection 2021 Jun.

3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography.

JACC. CardioOncology

Suvi Sirkku Tuohinen, Tanja Skyttä, Heini Huhtala, Tuija Poutanen, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen

Affiliations

  1. Heart and Lung Center, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland.
  2. Heart Hospital, Tampere University Hospital, University of Tampere, Tampere, Finland.
  3. Department of Oncology, Tampere University Hospital, Tampere, Finland.
  4. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  5. Faculty of Social Sciences, Tampere University, Tampere, Finland.
  6. Center for Child Health Research, Tampere, Finland.
  7. Department of Pediatrics, Faculty of Medicine and Heath Technology, Tampere University Hospital and Tampere University, Tampere, Finland.

PMID: 34396335 PMCID: PMC8352342 DOI: 10.1016/j.jaccao.2021.03.005

Abstract

BACKGROUND: Radiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function.

OBJECTIVES: The aim of this study was to explore RT-associated changes in left ventricular (LV) diastolic function.

METHODS: Sixty chemotherapy-naive patients with left-sided, early-stage breast cancer were studied with speckle tracking echocardiography at 3 time points: prior to, immediately after, and 3 years after RT. Global and regional early diastolic strain rate (SRe) were quantified, as were parameters of systolic function.

RESULTS: Regional changes in SRe, particularly the apical and anteroseptal segments, were observed over time and were more evident than global changes. The apical SRe declined from a median of 1.24 (interquartile range: 1.01 to 1.39) s

CONCLUSIONS: RT resulted in changes in the SRe in the apical and anteroseptal segments over 3 years of follow-up. Changes in SRe apical segments were present even in patients with preserved systolic function and were independently associated with RT dose and cardiovascular comorbidities.

© 2021 The Authors.

Keywords: CI, confidence interval; DLVmax, maximal left ventricular radiation dose; GLS, global longitudinal strain; IQR, interquartile range; LAVI, left atrial volume indexed to body surface area; LV, left ventricular; LVEF, left ventricular ejection fraction; RT, radiotherapy; SR, strain rate; SRe, early diastolic strain rate; SReapex, apical early diastolic strain rate; SRedep, global early diastolic strain rate <1 s-1; SRs, systolic strain rate; breast cancer; diastolic strain rate; radiotherapy; speckle tracking echocardiography; ΔGLS15, relative decline of more than 15% in global longitudinal strain

Conflict of interest statement

This study has received funding from nonprofit trusts: Paavo and Eila Salonen Legacy, the Finnish Foundation for Cardiovascular Research, and the Finnish Society of Oncology. The authors have reported

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