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Dribin TE, Schnadower D, Wang J, et al. Anaphylaxis knowledge gaps and future research priorities: A consensus report. J Allergy Clin Immunol. 2021;doi: 10.1016/j.jaci.2021.07.035.
Dribin, T. E., Schnadower, D., Wang, J., Camargo, C. A., Michelson, K. A., Shaker, M., Rudders, S. A., Vyles, D., Golden, D. B. K., Spergel, J. M., Campbell, R. L., Neuman, M. I., Capucilli, P. S., Pistiner, M., Castells, M., Lee, J., Brousseau, D. C., Schneider, L. C., Assa'ad, A. H., Risma, K. A., Mistry, R. D., Campbell, D. E., Worm, M., Turner, P. J., Witry, J. K., Zhang, Y., Sobolewski, B., & Sampson, H. A. (2021). Anaphylaxis knowledge gaps and future research priorities: A consensus report. The Journal of allergy and clinical immunology, . https://doi.org/10.1016/j.jaci.2021.07.035
Dribin, Timothy E, et al. "Anaphylaxis knowledge gaps and future research priorities: A consensus report." The Journal of allergy and clinical immunology vol. (2021). doi: https://doi.org/10.1016/j.jaci.2021.07.035
Dribin TE, Schnadower D, Wang J, Camargo CA, Michelson KA, Shaker M, Rudders SA, Vyles D, Golden DBK, Spergel JM, Campbell RL, Neuman MI, Capucilli PS, Pistiner M, Castells M, Lee J, Brousseau DC, Schneider LC, Assa'ad AH, Risma KA, Mistry RD, Campbell DE, Worm M, Turner PJ, Witry JK, Zhang Y, Sobolewski B, Sampson HA. Anaphylaxis knowledge gaps and future research priorities: A consensus report. J Allergy Clin Immunol. 2021 Aug 12; doi: 10.1016/j.jaci.2021.07.035. Epub 2021 Aug 12. PMID: 34390722.
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J Allergy Clin Immunol. 2021 Aug 12; doi: 10.1016/j.jaci.2021.07.035. Epub 2021 Aug 12.

Anaphylaxis knowledge gaps and future research priorities: A consensus report.

The Journal of allergy and clinical immunology

Timothy E Dribin, David Schnadower, Julie Wang, Carlos A Camargo, Kenneth A Michelson, Marcus Shaker, Susan A Rudders, David Vyles, David B K Golden, Jonathan M Spergel, Ronna L Campbell, Mark I Neuman, Peter S Capucilli, Michael Pistiner, Mariana Castells, Juhee Lee, David C Brousseau, Lynda C Schneider, Amal H Assa'ad, Kimberly A Risma, Rakesh D Mistry, Dianne E Campbell, Margitta Worm, Paul J Turner, John K Witry, Yin Zhang, Brad Sobolewski, Hugh A Sampson

Affiliations

  1. Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: [email protected].
  2. Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  3. Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.
  4. Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
  5. Division of Emergency Medicine, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass.
  6. Dartmouth Geisel School of Medicine, and Dartmouth-Hitchcock Medical Center, Hanover and Lebanon, NH.
  7. Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass.
  8. Section of Pediatric Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wis.
  9. Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
  10. Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pa.
  11. Department of Emergency Medicine, Mayo Clinic, Rochester, NY.
  12. Rochester Regional Health, Rochester, NY.
  13. Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Mass.
  14. Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  15. Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  16. Section of Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, Aurora, Colo.
  17. Sydney Medical School, University of Sydney, Sydney, Australia; Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, Australia.
  18. Division of Allergy and Immunology, Department of Dermatology and Allergology, Charite-Universitätsmedizin Berlin, Berlin, Germany.
  19. National Heart & Lung Institute, Imperial College London, London, United Kingdom.
  20. Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  21. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

PMID: 34390722 DOI: 10.1016/j.jaci.2021.07.035

Abstract

BACKGROUND: Despite a better understanding of the epidemiology, pathogenesis, and management of patients with anaphylaxis, there remain knowledge gaps. Enumerating and prioritizing these gaps would allow limited scientific resources to be directed more effectively.

OBJECTIVE: We sought to systematically describe and appraise anaphylaxis knowledge gaps and future research priorities based on their potential impact and feasibility.

METHODS: We convened a 25-member multidisciplinary panel of anaphylaxis experts. Panelists formulated knowledge gaps/research priority statements in an anonymous electronic survey. Four anaphylaxis themed writing groups were formed to refine statements: (1) Population Science, (2) Basic and Translational Sciences, (3) Emergency Department Care/Acute Management, and (4) Long-Term Management Strategies and Prevention. Revised statements were incorporated into an anonymous electronic survey, and panelists were asked to rate the impact and feasibility of addressing statements on a continuous 0 to 100 scale.

RESULTS: The panel generated 98 statements across the 4 anaphylaxis themes: Population Science (29), Basic and Translational Sciences (27), Emergency Department Care/Acute Management (24), and Long-Term Management Strategies and Prevention (18). Median scores for impact and feasibility ranged from 50.0 to 95.0 and from 40.0 to 90.0, respectively. Key statements based on median rating for impact/feasibility included the need to refine anaphylaxis diagnostic criteria, identify reliable diagnostic, predictive, and prognostic anaphylaxis bioassays, develop clinical prediction models to standardize postanaphylaxis observation periods and hospitalization criteria, and determine immunotherapy best practices.

CONCLUSIONS: We identified and systematically appraised anaphylaxis knowledge gaps and future research priorities. This study reinforces the need to harmonize scientific pursuits to optimize the outcomes of patients with and at risk of anaphylaxis.

Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Keywords: Allergy; anaphylaxis; basic science; emergency department; feasibility; impact; population science; research; translational science

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