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Borroto-Escuela DO, Ferraro L, Beggiato S, et al. The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons. Pharmacol Rep. 2021;73(4):1096-1108doi: 10.1007/s43440-021-00314-3.
Borroto-Escuela, D. O., Ferraro, L., Beggiato, S., Narváez, M., Fores-Pons, R., Alvarez-Contino, J. E., Wydra, K., Frankowska, M., Bader, M., Filip, M., & Fuxe, K. (2021). The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons. Pharmacological reports : PR, 73(4), 1096-1108. https://doi.org/10.1007/s43440-021-00314-3
Borroto-Escuela, Dasiel O, et al. "The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons." Pharmacological reports : PR vol. 73,4 (2021): 1096-1108. doi: https://doi.org/10.1007/s43440-021-00314-3
Borroto-Escuela DO, Ferraro L, Beggiato S, Narváez M, Fores-Pons R, Alvarez-Contino JE, Wydra K, Frankowska M, Bader M, Filip M, Fuxe K. The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons. Pharmacol Rep. 2021 Aug;73(4):1096-1108. doi: 10.1007/s43440-021-00314-3. Epub 2021 Aug 24. PMID: 34426901; PMCID: PMC8413191.
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Pharmacol Rep. 2021 Aug;73(4):1096-1108. doi: 10.1007/s43440-021-00314-3. Epub 2021 Aug 24.

The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons.

Pharmacological reports : PR

Dasiel O Borroto-Escuela, Luca Ferraro, Sarah Beggiato, Manuel Narváez, Ramon Fores-Pons, Jose E Alvarez-Contino, Karolina Wydra, Małgorzata Frankowska, Michael Bader, Małgorzata Filip, Kjell Fuxe

Affiliations

  1. Department of Neuroscience, Karolinska Institutet, Biomedicum (B0851), Solnavagen 9, 17177, Stockholm, Sweden. [email protected].
  2. Facultad de Medicina, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Campus de Teatinos s/n, 29071, Málaga, Spain. [email protected].
  3. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  4. Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100, Chieti, Italy.
  5. Facultad de Medicina, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Campus de Teatinos s/n, 29071, Málaga, Spain.
  6. Policlínico Universitario Juan Bruno Zayas, Cifuentes, Villa Clara, Cuba.
  7. Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Sm?tna Street, 31343, Kraków, Poland.
  8. Max-Delbrück-Centrum Für Molekulare Medizin (MDC), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.
  9. Department of Neuroscience, Karolinska Institutet, Biomedicum (B0851), Solnavagen 9, 17177, Stockholm, Sweden. [email protected].

PMID: 34426901 PMCID: PMC8413191 DOI: 10.1007/s43440-021-00314-3

Abstract

The role of adenosine A2A receptor (A2AR) and striatal-enriched protein tyrosine phosphatase (STEP) interactions in the striatal-pallidal GABA neurons was recently discussed in relation to A2AR overexpression and cocaine-induced increases of brain adenosine levels. As to phosphorylation, combined activation of A2AR and metabotropic glutamate receptor 5 (mGluR5) in the striatal-pallidal GABA neurons appears necessary for phosphorylation of the GluA1 unit of the AMPA receptor to take place. Robert Yasuda (J Neurochem 152: 270-272, 2020) focused on finding a general mechanism by which STEP activation is enhanced by increased A2AR transmission in striatal-pallidal GABA neurons expressing A2AR and dopamine D2 receptor. In his Editorial, he summarized in a clear way the significant effects of A2AR activation on STEP in the dorsal striatal-pallidal GABA neurons which involves a rise of intracellular levels of calcium causing STEP activation through its dephosphorylation. However, the presence of the A2AR in an A2AR-fibroblast growth factor receptor 1 (FGFR1) heteroreceptor complex can be required in the dorsal striatal-pallidal GABA neurons for the STEP activation. Furthermore, Won et al. (Proc Natl Acad Sci USA 116: 8028-8037, 2019) found in mass spectrometry experiments that the STEP splice variant STEP

© 2021. The Author(s).

Keywords: Adenosine A2A receptor; Allosteric receptor–receptor interactions; Cocaine; Oligomerization; Phosphorylation; Striatal-enriched protein tyrosine phosphatase

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