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Bin Jardan YA, Ahad A, Raish M, et al. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol. 2021;59(1):1088-1097doi: 10.1080/13880209.2021.1961817.
Bin Jardan, Y. A., Ahad, A., Raish, M., Alam, M. A., Al-Mohizea, A. M., & Al-Jenoobi, F. I. (2021). Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharmaceutical biology, 59(1), 1088-1097. https://doi.org/10.1080/13880209.2021.1961817
Bin Jardan, Yousef A, et al. "Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension." Pharmaceutical biology vol. 59,1 (2021): 1088-1097. doi: https://doi.org/10.1080/13880209.2021.1961817
Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol. 2021 Dec;59(1):1088-1097. doi: 10.1080/13880209.2021.1961817. PMID: 34392777; PMCID: PMC8366631.
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Pharm Biol. 2021 Dec;59(1):1088-1097. doi: 10.1080/13880209.2021.1961817.

Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.

Pharmaceutical biology

Yousef A Bin Jardan, Abdul Ahad, Mohammad Raish, Mohd Aftab Alam, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi

Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

PMID: 34392777 PMCID: PMC8366631 DOI: 10.1080/13880209.2021.1961817

Abstract

CONTEXT: Garden cress (GC), fenugreek (FG), and black seed (BS) are traditional herbal medicine for managing hypertension.

OBJECTIVE: The effects of the three herbs on the pharmacodynamics of metoprolol tartrate (MT) in hypertensive rats were investigated.

MATERIALS AND METHODS: Wistar rats were divided in five groups (

RESULTS: GC, FG, and BS decreased systolic blood pressure (SBP) by 8.7%, 8.5%, and 8.7%, respectively, in hypertensive rats. A greater decrease in SBP by 14.5%, 14.8%, and 16.1% was observed when hypertensive rats were treated with L-NAME + GC + MT, L-NAME + FG + MT, and L-NAME + BS + MT, respectively. Similarly, hypertensive rats treated with the combination of herbs and MT had significantly lower diastolic blood pressure (DBP) than those treated with herbs alone and those treated with L-NAME alone.

CONCLUSIONS: The combination of investigated herbs and MT had a beneficial effect on hypertension. However, the concurrent administration of drugs, particularly those predominantly cleared through CYP450 2D6-catalyzed metabolism, with the three investigated herbs should be considered with caution.

Keywords: Blood pressure; CYP2D6; Lepidium sativum; Nigella sativa; Trigonella foenum-graecum; herbal medicine

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