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Quispe-Salcedo A, Ohshima H. The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis. J Clin Med. 2021;10(15)doi: 10.3390/jcm10153348.
Quispe-Salcedo, A., & Ohshima, H. (2021). The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis. Journal of clinical medicine, 10(15), . https://doi.org/10.3390/jcm10153348
Quispe-Salcedo, Angela, and Ohshima, Hayato. "The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis." Journal of clinical medicine vol. 10,15 (2021). doi: https://doi.org/10.3390/jcm10153348
Quispe-Salcedo A, Ohshima H. The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis. J Clin Med. 2021 Jul 29;10(15). doi: 10.3390/jcm10153348. PMID: 34362130; PMCID: PMC8348392.
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J Clin Med. 2021 Jul 29;10(15). doi: 10.3390/jcm10153348.

The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis.

Journal of clinical medicine

Angela Quispe-Salcedo, Hayato Ohshima

Affiliations

  1. Department of Tissue Regeneration and Reconstruction, Division of Anatomy and Cell Biology of the Hard Tissue, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan.
  2. Department of Stomatology, Faculty of Health Sciences, School of Stomatology, Universidad Cientifica del Sur, Lima 15067, Peru.

PMID: 34362130 PMCID: PMC8348392 DOI: 10.3390/jcm10153348

Abstract

The dental pulp is a soft connective tissue of ectomesenchymal origin that harbors distinct cell populations, capable of interacting with each other to maintain the vitality of the tooth. After tooth injuries, a sequence of complex biological events takes place in the pulpal tissue to restore its homeostasis. The pulpal response begins with establishing an inflammatory reaction that leads to the formation of a matrix of reactionary or reparative dentin, according to the nature of the exogenous stimuli. Using several in vivo designs, antigen-presenting cells, including macrophages and dendritic cells (DCs), are identified in the pulpal tissue before tertiary dentin deposition under the afflicted area. However, the precise nature of this phenomenon and its relationship to inherent pulp cells are not yet clarified. This literature review aims to discuss the role of pulpal DCs and their relationship to progenitor/stem cells, odontoblasts or odontoblast-like cells, and other immunocompetent cells during physiological and pathological dentinogenesis. The concept of "dentin-pulp immunology" is proposed for understanding the crosstalk among these cell types after tooth injuries, and the possibility of immune-based therapies is introduced to accelerate pulpal healing after exogenous stimuli.

Keywords: cell differentiation; dendritic cells; dental pulp; dentin; extracellular matrix proteins; histocompatibility antigens class II; macrophages; odontoblasts; stem cells; tooth injuries

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