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Santos Lucio A, Rodríguez Tirado I, Aparicio Serrano A, et al. Hallazgos endoscópicos no relacionados con hipertensión portal en pacientes con cirrosis hepática sometidos a un programa de cribado de varices. Endoscopic findings unrelated to portal hypertension in patients with liver cirrhosis undergoing a varicose vein screening programme. Gastroenterol Hepatol. 2021;doi: 10.1016/j.gastrohep.2021.07.010.
Santos Lucio, A., Rodríguez Tirado, I., Aparicio Serrano, A., Jurado García, J., Barrera Baena, P., González Galilea, �. �., Poyato González, A., Pleguezuelo Navarro, M., Costán Rodero, G., Casáis Juanena, L., Montero Álvarez, J. L., de la Mata, M., Hervás Molina, A. J., & Rodríguez-Perálvarez, M. L. (2021). Hallazgos endoscópicos no relacionados con hipertensión portal en pacientes con cirrosis hepática sometidos a un programa de cribado de varices. Endoscopic findings unrelated to portal hypertension in patients with liver cirrhosis undergoing a varicose vein screening programme. Gastroenterologia y hepatologia, . https://doi.org/10.1016/j.gastrohep.2021.07.010
Santos Lucio, Ana, et al. "Hallazgos endoscópicos no relacionados con hipertensión portal en pacientes con cirrosis hepática sometidos a un programa de cribado de varices." Endoscopic findings unrelated to portal hypertension in patients with liver cirrhosis undergoing a varicose vein screening programme. Gastroenterologia y hepatologia vol. (2021). doi: https://doi.org/10.1016/j.gastrohep.2021.07.010
Santos Lucio A, Rodríguez Tirado I, Aparicio Serrano A, Jurado García J, Barrera Baena P, González Galilea Á, Poyato González A, Pleguezuelo Navarro M, Costán Rodero G, Casáis Juanena L, Montero Álvarez JL, de la Mata M, Hervás Molina AJ, Rodríguez-Perálvarez ML. Hallazgos endoscópicos no relacionados con hipertensión portal en pacientes con cirrosis hepática sometidos a un programa de cribado de varices. Endoscopic findings unrelated to portal hypertension in patients with liver cirrhosis undergoing a varicose vein screening programme. Gastroenterol Hepatol. 2021 Aug 14; doi: 10.1016/j.gastrohep.2021.07.010. Epub 2021 Aug 14. Spanish. PMID: 34400186.
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Gastroenterol Hepatol. 2021 Aug 14; doi: 10.1016/j.gastrohep.2021.07.010. Epub 2021 Aug 14.

Endoscopic findings unrelated to portal hypertension in patients with liver cirrhosis undergoing a varicose vein screening programme.

Gastroenterologia y hepatologia

[Article in Spanish]
Ana Santos Lucio, Isabel Rodríguez Tirado, Ana Aparicio Serrano, Juan Jurado García, Pilar Barrera Baena, Ángel González Galilea, Antonio Poyato González, María Pleguezuelo Navarro, Guadalupe Costán Rodero, Luis Casáis Juanena, José Luis Montero Álvarez, Manuel de la Mata, Antonio José Hervás Molina, Manuel Luis Rodríguez-Perálvarez

Affiliations

  1. Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía, IMIBIC, Córdoba, España.
  2. Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía, IMIBIC, Córdoba, España; CIBER de enfermedades hepáticas y digestivas (CIBERehd), Madrid, España.
  3. Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía, IMIBIC, Córdoba, España; CIBER de enfermedades hepáticas y digestivas (CIBERehd), Madrid, España; Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Córdoba, Córdoba, España.
  4. Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía, IMIBIC, Córdoba, España; CIBER de enfermedades hepáticas y digestivas (CIBERehd), Madrid, España; Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Córdoba, Córdoba, España. Electronic address: [email protected].

PMID: 34400186 DOI: 10.1016/j.gastrohep.2021.07.010

Abstract

AIM: To determine the prevalence of endoscopic lesions unrelated with portal hypertension in patients with cirrhosis.

PATIENTS AND METHODS: Cross-sectional study including a consecutive cohort of patients with liver cirrhosis enrolled in a screening program of oesophageal varices who underwent an upper gastrointestinal endoscopy from November, 2013, to November, 2018. Clinical predictors of endoscopic lesions unrelated to portal hypertension were analyzed by univariate and multivariate logistic regression.

RESULTS: A total of 379 patients were included. The most frequent aetiology of liver disease was alcohol consumption (60.4%). The prevalence of endoscopic lesions unrelated with portal hypertension was 39.6% (n=150). Among 96 patients with peptic lesions, urease was obtained in 56.2% of patients (positive in 44.4% of them). The prevalence of endoscopic lesions unrelated to portal hypertension was not associated with age, gender, liver function or ultrasound findings of portal hypertension. The prevalence of endoscopic lesions unrelated to portal hypertension was not associated with age, gender, liver function or ultrasound findings of portal hypertension. Smokers had a trend to increased prevalence of endoscopic lesions unrelated to portal hypertension (43.2% vs. 34.6%; p=0.09), particularly peptic ulcer (6.4% vs. 0.6%; p=0.05) and peptic duodenitis (17.3% vs. 6.3%; p=0.002). Active smoking was the only independent predictor of peptic ulcer or duodenitis (OR=2.56; p=0.017).

CONCLUSION: Active smoking is a risk factor for endoscopic lesions unrelated to portal hypertension. This finding should be further investigated to reassess endoscopic screening programs in cirrhotic smokers.

Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

Keywords: Cirrhosis; Cirrosis hepática; Endoscopia digestiva; Hipertensión portal; Peptic ulcer; Portal hypertension; Upper gastrointestinal endoscopy; Úlcera péptica

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