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Kumar A, Elko E, Bruno SR, et al. Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax. 2021;doi: 10.1136/thoraxjnl-2021-216882.
Kumar, A., Elko, E., Bruno, S. R., Mark, Z. F., Chamberlain, N., Mihavics, B. K., Chandrasekaran, R., Walzer, J., Ruban, M., Gold, C., Lam, Y. W., Ghandikota, S., Jegga, A. G., Gomez, J. L., Janssen-Heininger, Y. M., & Anathy, V. (2021). Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax, . https://doi.org/10.1136/thoraxjnl-2021-216882
Kumar, Amit, et al. "Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis." Thorax vol. (2021). doi: https://doi.org/10.1136/thoraxjnl-2021-216882
Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis. Thorax. 2021 Aug 16; doi: 10.1136/thoraxjnl-2021-216882. Epub 2021 Aug 16. PMID: 34400514.
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Thorax. 2021 Aug 16; doi: 10.1136/thoraxjnl-2021-216882. Epub 2021 Aug 16.

Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.

Thorax

Amit Kumar, Evan Elko, Sierra R Bruno, Zoe F Mark, Nicolas Chamberlain, Bethany Korwin Mihavics, Ravishankar Chandrasekaran, Joseph Walzer, Mona Ruban, Clarissa Gold, Ying Wai Lam, Sudhir Ghandikota, Anil G Jegga, Jose L Gomez, Yvonne Mw Janssen-Heininger, Vikas Anathy

Affiliations

  1. Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
  2. Department of Pulmonary, Critical Care Medicine, Larner College of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
  3. Department of Biology & Vermont Biomedical Research Network Proteomics Facility, University of Vermont, Burlington, Vermont, USA.
  4. Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  5. Department of Computer Science, University of Cincinnati College of Engineering and Applied Science, Cincinnati, Ohio, USA.
  6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
  7. Internal Medicine-Pulmonary, Critical Care and Sleep Section, Yale University School of Medicine, New Haven, Connecticut, USA.
  8. Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA [email protected].

PMID: 34400514 DOI: 10.1136/thoraxjnl-2021-216882

Abstract

CONCLUSIONS: Our study reveals a new relationship with distally localised club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: idiopathic pulmonary fibrosis; interstitial fibrosis

Conflict of interest statement

Competing interests: YMWJ-H and VA hold patents: United States Patent No. 8,679,811, 'Treatments Involving Glutaredoxins and Similar Agents', United States Patent No. 8,877,447, 'Detection of Glutathi

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