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Pessoa Rodrigues C, Akhtar A. Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Sci Adv. 2021;7(32)doi: 10.1126/sciadv.abi5987.
Pessoa Rodrigues, C., & Akhtar, A. (2021). Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science advances, 7(32), . https://doi.org/10.1126/sciadv.abi5987
Pessoa Rodrigues, Cecilia, and Akhtar, Asifa. "Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells." Science advances vol. 7,32 (2021). doi: https://doi.org/10.1126/sciadv.abi5987
Pessoa Rodrigues C, Akhtar A. Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Sci Adv. 2021 Aug 06;7(32). doi: 10.1126/sciadv.abi5987. Print 2021 Aug. PMID: 34362741; PMCID: PMC8346211.
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Sci Adv. 2021 Aug 06;7(32). doi: 10.1126/sciadv.abi5987. Print 2021 Aug.

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells.

Science advances

Cecilia Pessoa Rodrigues, Asifa Akhtar

Affiliations

  1. Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
  2. Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, 79104 Freiburg, Germany.
  3. International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany.
  4. Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. [email protected].

PMID: 34362741 PMCID: PMC8346211 DOI: 10.1126/sciadv.abi5987

Abstract

Hematopoietic stem cells (HSCs) are able to reconstitute the bone marrow while retaining their self-renewal property. Individual HSCs demonstrate heterogeneity in their repopulating capacities. Here, we found that the levels of the histone acetyltransferase MOF (males absent on the first) and its target modification histone H4 lysine 16 acetylation are heterogeneous among HSCs and influence their proliferation capacities. The increased proliferative capacities of MOF-depleted cells are linked to their expression of CD93. The CD93

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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