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Hodge SE, Lopez IA, Ishiyama G, et al. Cisplatin ototoxicity histopathology. Laryngoscope Investig Otolaryngol. 2021;6(4):852-856doi: 10.1002/lio2.608.
Hodge, S. E., Lopez, I. A., Ishiyama, G., & Ishiyama, A. (2021). Cisplatin ototoxicity histopathology. Laryngoscope investigative otolaryngology, 6(4), 852-856. https://doi.org/10.1002/lio2.608
Hodge, Sarah E, et al. "Cisplatin ototoxicity histopathology." Laryngoscope investigative otolaryngology vol. 6,4 (2021): 852-856. doi: https://doi.org/10.1002/lio2.608
Hodge SE, Lopez IA, Ishiyama G, Ishiyama A. Cisplatin ototoxicity histopathology. Laryngoscope Investig Otolaryngol. 2021 Jun 28;6(4):852-856. doi: 10.1002/lio2.608. eCollection 2021 Aug. PMID: 34401512; PMCID: PMC8356863.
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Laryngoscope Investig Otolaryngol. 2021 Jun 28;6(4):852-856. doi: 10.1002/lio2.608. eCollection 2021 Aug.

Cisplatin ototoxicity histopathology.

Laryngoscope investigative otolaryngology

Sarah E Hodge, Ivan A Lopez, Gail Ishiyama, Akira Ishiyama

Affiliations

  1. House Ear Clinic Los Angeles California USA.
  2. Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California USA.
  3. Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA.

PMID: 34401512 PMCID: PMC8356863 DOI: 10.1002/lio2.608

Abstract

This study investigates the histopathological changes of the cochlea and vestibular end organs of a patient who received cisplatin for Hodgkin's lymphoma. He experienced acute high-frequency sensorineural hearing loss and tinnitus after receiving treatment. Using histopathological analysis of his temporal bones after he unfortunately succumbed to his disease, we found that the ototoxic effect of cisplatin is primarily within the cochlea, with significant damage located at the organ of Corti at the base-hook region, consistent with findings in animal models. The effects of cisplatin were minimal when reviewing the vestibular end organs.

© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.

Keywords: cisplatin; ototoxicity; temporal bone; vestibular end organs

Conflict of interest statement

The authors declare no conflict of interest to report.

References

  1. Hear Res. 2007 Apr;226(1-2):157-67 - PubMed
  2. Otol Neurotol. 2016 Dec;37(10):1516-1521 - PubMed
  3. J Otol. 2018 Dec;13(4):115-121 - PubMed

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