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Fortich S, Ritchie C, Shaikh ME, et al. Deep vein thrombosis in the setting of Klippel-Trenaunay syndrome and sirolimus treatment. J Vasc Surg Cases Innov Tech. 2021;7(3):524-528doi: 10.1016/j.jvscit.2021.06.014.
Fortich, S., Ritchie, C., Shaikh, M. E., Toskich, B., Rivera, C. E., & Erben, Y. (2021). Deep vein thrombosis in the setting of Klippel-Trenaunay syndrome and sirolimus treatment. Journal of vascular surgery cases and innovative techniques, 7(3), 524-528. https://doi.org/10.1016/j.jvscit.2021.06.014
Fortich, Susana, et al. "Deep vein thrombosis in the setting of Klippel-Trenaunay syndrome and sirolimus treatment." Journal of vascular surgery cases and innovative techniques vol. 7,3 (2021): 524-528. doi: https://doi.org/10.1016/j.jvscit.2021.06.014
Fortich S, Ritchie C, Shaikh ME, Toskich B, Rivera CE, Erben Y. Deep vein thrombosis in the setting of Klippel-Trenaunay syndrome and sirolimus treatment. J Vasc Surg Cases Innov Tech. 2021 Jul 17;7(3):524-528. doi: 10.1016/j.jvscit.2021.06.014. eCollection 2021 Sep. PMID: 34401617; PMCID: PMC8358289.
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J Vasc Surg Cases Innov Tech. 2021 Jul 17;7(3):524-528. doi: 10.1016/j.jvscit.2021.06.014. eCollection 2021 Sep.

Deep vein thrombosis in the setting of Klippel-Trenaunay syndrome and sirolimus treatment.

Journal of vascular surgery cases and innovative techniques

Susana Fortich, Charles Ritchie, Marwan E Shaikh, Beau Toskich, Candido E Rivera, Young Erben

Affiliations

  1. Division of Vascular and Endovascular Surgery, Mayo Clinic Florida, Jacksonville, Fla.
  2. Division of Vascular and Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla.
  3. Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, Fla.

PMID: 34401617 PMCID: PMC8358289 DOI: 10.1016/j.jvscit.2021.06.014

Abstract

Klippel-Trenaunay syndrome (KTS) is a congenital vascular disorder characterized by the triad of cutaneous capillary malformation, lymphatic and venous anomalies, and soft tissue and bone overgrowth. Sirolimus is a mechanistic target of rapamycin inhibitor used as an immunosuppressive drug. It has also been used to improve and treat vascular malformations that can predispose to intravascular coagulopathy. We have described the case of a patient with KTS receiving a therapeutic anticoagulation dose, for whom sirolimus was initiated, and who had presented with an extensive venous thromboembolism. Correlations between the use of sirolimus in patients with KTS are limited, and cautious use and monitoring could be necessary.

© 2021 The Author(s).

Keywords: Deep venous thrombosis; Klippel Trenaunay syndrome; Sirolimus

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