Malays Orthop J. 2021 Jul;15(2):143-150. doi: 10.5704/MOJ.2107.021.
C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR) Trends following Total Hip and Knee Arthroplasties in an Indian Population - A Prospective Study.
Malaysian orthopaedic journal
A Krishna, S Garg, S Gupta, H Bansal
Affiliations
Affiliations
- Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.
- Department of Orthopaedics, Government Medical College and Hospital, Chandigarh, India.
- Department of Orthopaedics, Fortis Hospital Mohali, Chandigarh, India.
PMID: 34429835
PMCID: PMC8381678 DOI: 10.5704/MOJ.2107.021
Abstract
INTRODUCTION: To evaluate the trends of C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) in the first three weeks after uncomplicated total hip (THR) and total knee (TKR) arthroplasty/replacement in the Indian population and to compare it with available literature.
MATERIALS AND METHODS: A total of 90 patients were enrolled for this prospective study, of which 30 were unilateral THR, 30 were unilateral TKR (U/L TKR) and 30 were simultaneous bilateral TKR (B/L TKR). Serum CRP and ESR were measured on the day before surgery and post-operatively on day 1st, 2nd, 3rd, 7th, 12th, and at the end of 3rd week.
RESULTS: CRP showed a peak at day 2nd with normalisation to pre-operative value by the end of 3rd week. While ESR showed a peak on day 3rd and continued to remain elevated even at end of 3rd week post-operatively. Both mean CRP and ESR values were higher in THR patients followed by in B/L TKR and then in U/L TKR patients.
CONCLUSION: CRP persists to be the best acute phase reactant in the early post-operative phase with a relatively typical pattern as compared to ESR. CRP values peak at post-operative day 2nd and then show a gradual decline. However, its normalisation to pre-operative baseline values may vary among different groups of population.
© 2021 Malaysian Orthopaedic Association (MOA). All Rights Reserved.
Keywords: CRP; ESR; Indian population; total hip arthroplasty; total knee arthroplasty
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