Display options
Cite
Levy AP, Levy NS, Heyman E, et al. Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi. Clin Case Rep. 2021;9(9):e04734doi: 10.1002/ccr3.4734.
Levy, A. P., Levy, N. S., Heyman, E., Schertz, M., & Genizi, J. (2021). Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi. Clinical case reports, 9(9), e04734. https://doi.org/10.1002/ccr3.4734
Levy, Andrew P, et al. "Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi." Clinical case reports vol. 9,9 (2021): e04734. doi: https://doi.org/10.1002/ccr3.4734
Levy AP, Levy NS, Heyman E, Schertz M, Genizi J. Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi. Clin Case Rep. 2021 Aug 30;9(9):e04734. doi: 10.1002/ccr3.4734. eCollection 2021 Sep. PMID: 34484768; PMCID: PMC8405536.
Copy Download .nbib Format: NLM
Share it on

Clin Case Rep. 2021 Aug 30;9(9):e04734. doi: 10.1002/ccr3.4734. eCollection 2021 Sep.

Reduction in seizure burden in a child with a A350V IQSEC2 mutation using heat therapy with a Jacuzzi.

Clinical case reports

Andrew P Levy, Nina S Levy, Eli Heyman, Mitchell Schertz, Jacob Genizi

Affiliations

  1. Technion Israel Institute of Technology Technion Faculty of Medicine Department of Biochemistry Haifa Israel.
  2. Department of Pediatric Neurology Assaf Harofeh Medical Center and Tel Aviv University Tel Aviv Israel.
  3. Child Development and Pediatric Neurology Service Mehudet North and Technion Israel Institute of Technology Haifa Israel.
  4. Bnai Zion Medical Center and Technion Israel Institute of Technology Pediatric Neurology Unit Haifa Israel.

PMID: 34484768 PMCID: PMC8405536 DOI: 10.1002/ccr3.4734

Abstract

A child with a A350V IQSEC2 missense mutation resulting in drug-resistant epilepsy stops having seizures when he has a fever. We demonstrate that raising the body temperature of the child using a commercial Jacuzzi dramatically reduces his seizures and appears to improve his social behavioral interactions.

© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

Keywords: IQSEC2; child development; epilepsy; heat shock; thermal therapy

Conflict of interest statement

None declared.

References

  1. Pediatrics. 2007 Dec;120(6):e1386-92 - PubMed
  2. Front Physiol. 2020 Jan 10;10:1556 - PubMed
  3. Trends Cell Biol. 2019 Feb;29(2):164-177 - PubMed
  4. Cell. 2017 Feb 23;168(5):856-866.e12 - PubMed
  5. Temperature (Austin). 2017 Mar 9;4(3):292-304 - PubMed
  6. Environ Med. 1994;38(1):77-80 - PubMed
  7. Hum Mutat. 2019 Jan;40(1):5-24 - PubMed
  8. Front Cell Neurosci. 2015 Mar 12;9:68 - PubMed
  9. Epilepsia. 2016 Nov;57(11):1858-1869 - PubMed
  10. Genet Med. 2019 Apr;21(4):837-849 - PubMed
  11. Aviat Space Environ Med. 1998 Sep;69(9):845-50 - PubMed
  12. Front Mol Neurosci. 2019 Feb 20;12:43 - PubMed
  13. Cell Stress Chaperones. 2000 Nov;5(5):471-80 - PubMed
  14. Clin Case Rep. 2017 Aug 24;5(10):1639-1643 - PubMed
  15. Mol Cell Biochem. 2014 Jan;386(1-2):45-61 - PubMed
  16. Autism Res. 2018 Jan;11(1):175-184 - PubMed
  17. Nat Genet. 2010 Jun;42(6):486-8 - PubMed
  18. Neurobiol Dis. 2005 Jun-Jul;19(1-2):142-9 - PubMed

Publication Types