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Orimo K, Tamari M, Takeda T, et al. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. Allergy. 2021;doi: 10.1111/all.15057.
Orimo, K., Tamari, M., Takeda, T., Kubo, T., Rückert, B., Motomura, K., Sugiyama, H., Yamada, A., Saito, K., Arae, K., Kuriyama, M., Hara, M., Soyka, M. B., Ikutani, M., Yamaguchi, S., Morimoto, N., Nakabayashi, K., Hata, K., Matsuda, A., Akdis, C. A., Sudo, K., Saito, H., Nakae, S., Tamaoki, J., Tagaya, E., Matsumoto, K., & Morita, H. (2021). Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. Allergy, . https://doi.org/10.1111/all.15057
Orimo, Keisuke, et al. "Direct platelet adhesion potentiates group 2 innate lymphoid cell functions." Allergy vol. (2021). doi: https://doi.org/10.1111/all.15057
Orimo K, Tamari M, Takeda T, Kubo T, Rückert B, Motomura K, Sugiyama H, Yamada A, Saito K, Arae K, Kuriyama M, Hara M, Soyka MB, Ikutani M, Yamaguchi S, Morimoto N, Nakabayashi K, Hata K, Matsuda A, Akdis CA, Sudo K, Saito H, Nakae S, Tamaoki J, Tagaya E, Matsumoto K, Morita H. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. Allergy. 2021 Aug 17; doi: 10.1111/all.15057. Epub 2021 Aug 17. PMID: 34402091.
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Allergy. 2021 Aug 17; doi: 10.1111/all.15057. Epub 2021 Aug 17.

Direct platelet adhesion potentiates group 2 innate lymphoid cell functions.

Allergy

Keisuke Orimo, Masato Tamari, Tomohiro Takeda, Terufumi Kubo, Beate Rückert, Kenichiro Motomura, Hiroki Sugiyama, Ayako Yamada, Kyoko Saito, Ken Arae, Motohiro Kuriyama, Mariko Hara, Michael B Soyka, Masashi Ikutani, Sota Yamaguchi, Noriko Morimoto, Kazuhiko Nakabayashi, Kenichiro Hata, Akio Matsuda, Cezmi A Akdis, Katsuko Sudo, Hirohisa Saito, Susumu Nakae, Jun Tamaoki, Etsuko Tagaya, Kenji Matsumoto, Hideaki Morita

Affiliations

  1. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
  2. Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
  3. Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
  4. Department of Health Science, Kansai University of Health Sciences, Osaka, Japan.
  5. Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  6. Swiss Institute of Allergy and Asthma Research (SIAF, University of Zurich, Davos, Switzerland.
  7. Department of Otorhinolaryngology Head and Neck Surgery, University of Fukui, Fukui, Japan.
  8. Department of Immunology, Faculty of Health Sciences, Kyorin University, Tokyo, Japan.
  9. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
  10. Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima City, Japan.
  11. Department of Immune Regulation, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
  12. Division of Otolaryngology, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
  13. Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
  14. Animal Research Center, Tokyo Medical University, Tokyo, Japan.
  15. Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  16. Precursory Research for Embryonic Science and Technology (PRESTO, Japan Science and Technology Agency, Saitama, Japan.
  17. Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

PMID: 34402091 DOI: 10.1111/all.15057

Abstract

BACKGROUND: Platelets are thought to be involved in the pathophysiology of asthma, presumably through direct adhesion to inflammatory cells, including group 2 innate lymphoid cells (ILC2s). Here, we tried to elucidate the effects of platelet adhesion to ILC2s in vitro and in vivo, as well as the mechanisms involved.

METHODS: Alternaria-induced ILC2-dependent airway inflammation models using wild-type and c-mpl

RESULTS: T2 inflammation and T2 cytokine production from ILC2s were significantly reduced in the c-mpl

CONCLUSION: Platelets spontaneously adhere to ILC2s, probably in the peripheral blood and airways, thereby potentiating ILC2s to enhance their responses to IL-33.

© 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Keywords: T2 cytokines; adhesion; asthma; group 2 innate lymphoid cells; platelets

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