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Mukai K, Sugimoto H, Kamiya K, et al. Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Curr Res Struct Biol. 2021;3:192-205doi: 10.1016/j.crstbi.2021.08.001.
Mukai, K., Sugimoto, H., Kamiya, K., Suzuki, R., Matsuura, T., Hishiki, T., Shimada, H., Shiro, Y., Suematsu, M., & Kagawa, N. (2021). Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Current research in structural biology, 3192-205. https://doi.org/10.1016/j.crstbi.2021.08.001
Mukai, Kuniaki, et al. "Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis." Current research in structural biology vol. 3 (2021): 192-205. doi: https://doi.org/10.1016/j.crstbi.2021.08.001
Mukai K, Sugimoto H, Kamiya K, Suzuki R, Matsuura T, Hishiki T, Shimada H, Shiro Y, Suematsu M, Kagawa N. Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Curr Res Struct Biol. 2021 Aug 26;3:192-205. doi: 10.1016/j.crstbi.2021.08.001. eCollection 2021. PMID: 34485929; PMCID: PMC8408562.
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Curr Res Struct Biol. 2021 Aug 26;3:192-205. doi: 10.1016/j.crstbi.2021.08.001. eCollection 2021.

Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis.

Current research in structural biology

Kuniaki Mukai, Hiroshi Sugimoto, Katsumasa Kamiya, Reiko Suzuki, Tomomi Matsuura, Takako Hishiki, Hideo Shimada, Yoshitsugu Shiro, Makoto Suematsu, Norio Kagawa

Affiliations

  1. Department of Biochemistry, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
  2. Medical Education Center, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
  3. Synchrotron Radiation Life Science Instrumentation Team, RIKEN SPring-8 Center, Sayo, Hyogo 679-5148, Japan.
  4. Center for Basic Education and Integrated Learning, Kanagawa Institute of Technology, Atsugi, Kanagawa 243-0292, Japan.
  5. Clinical and Translational Research Center, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
  6. Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo 678-1297, Japan.
  7. Office of CIBoG, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.

PMID: 34485929 PMCID: PMC8408562 DOI: 10.1016/j.crstbi.2021.08.001

Abstract

Human cytochromes P450

© 2021 The Authors.

Keywords: Adrenal; Cytochrome P450; DOC, 11-deoxycorticosterone; DOF, 11-deoxycortisol; Molecular dynamics; Steroid hormone; X-ray crystallography

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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