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Hegemann JD, Süssmuth RD. Matters of class: coming of age of class III and IV lanthipeptides. RSC Chem Biol. 2020;1(3):110-127doi: 10.1039/d0cb00073f.
Hegemann, J. D., & Süssmuth, R. D. (2020). Matters of class: coming of age of class III and IV lanthipeptides. RSC chemical biology, 1(3), 110-127. https://doi.org/10.1039/d0cb00073f
Hegemann, Julian D, and Süssmuth, Roderich D. "Matters of class: coming of age of class III and IV lanthipeptides." RSC chemical biology vol. 1,3 (2020): 110-127. doi: https://doi.org/10.1039/d0cb00073f
Hegemann JD, Süssmuth RD. Matters of class: coming of age of class III and IV lanthipeptides. RSC Chem Biol. 2020 Jul 16;1(3):110-127. doi: 10.1039/d0cb00073f. eCollection 2020 Aug 01. PMID: 34458752; PMCID: PMC8341899.
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RSC Chem Biol. 2020 Jul 16;1(3):110-127. doi: 10.1039/d0cb00073f. eCollection 2020 Aug 01.

Matters of class: coming of age of class III and IV lanthipeptides.

RSC chemical biology

Julian D Hegemann, Roderich D Süssmuth

Affiliations

  1. Institute of Chemistry, Technische Universität Berlin, Straße des 17. Juni 124 10623 Berlin Germany [email protected] [email protected].

PMID: 34458752 PMCID: PMC8341899 DOI: 10.1039/d0cb00073f

Abstract

Lanthipeptides belong to the superfamily of ribosomally-synthesized and posttranslationally-modified peptides (RiPPs). Despite the fact that they represent one of the longest known RiPP subfamilies, their youngest members, classes III and IV, have only been described more recently. Since then, a plethora of studies furthered the understanding of their biosynthesis. While there are commonalities between classes III and IV due to the similar domain architectures of their processing enzymes, there are also striking differences that allow their discrimination. In this concise review article, we summarize what is known about the underlying biosynthetic principles of these lanthipeptides and discuss open questions for future research.

This journal is © The Royal Society of Chemistry.

Conflict of interest statement

There are no conflicts to declare.

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