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Limaye AJ, Bendzunas GN, Kennedy EJ. Targeted disruption of PKC from AKAP signaling complexes. RSC Chem Biol. 2021;2(4):1227-1231doi: 10.1039/d1cb00106j.
Limaye, A. J., Bendzunas, G. N., & Kennedy, E. J. (2021). Targeted disruption of PKC from AKAP signaling complexes. RSC chemical biology, 2(4), 1227-1231. https://doi.org/10.1039/d1cb00106j
Limaye, Ameya J, et al. "Targeted disruption of PKC from AKAP signaling complexes." RSC chemical biology vol. 2,4 (2021): 1227-1231. doi: https://doi.org/10.1039/d1cb00106j
Limaye AJ, Bendzunas GN, Kennedy EJ. Targeted disruption of PKC from AKAP signaling complexes. RSC Chem Biol. 2021 Jul 19;2(4):1227-1231. doi: 10.1039/d1cb00106j. eCollection 2021 Aug 05. PMID: 34458835; PMCID: PMC8341804.
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RSC Chem Biol. 2021 Jul 19;2(4):1227-1231. doi: 10.1039/d1cb00106j. eCollection 2021 Aug 05.

Targeted disruption of PKC from AKAP signaling complexes.

RSC chemical biology

Ameya J Limaye, George N Bendzunas, Eileen J Kennedy

Affiliations

  1. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens GA 30602 USA [email protected].

PMID: 34458835 PMCID: PMC8341804 DOI: 10.1039/d1cb00106j

Abstract

Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide array of signaling pathways and physiological processes. Protein-protein interactions involving PKC and its scaffolding partners dictate the spatiotemporal dynamics of PKC activity, including its access to activating second messenger molecules and potential substrates. While the A Kinase Anchoring Protein (AKAP) family of scaffold proteins universally bind PKA, several were also found to scaffold PKC, thereby serving to tune its catalytic output. Targeting these scaffolding interactions can further shed light on the effect of subcellular compartmentalization on PKC signaling. Here we report the development of two hydrocarbon stapled peptides, CSTAD5 and CSTAD6, that are cell permeable and bind PKC to disrupt PKC

This journal is © The Royal Society of Chemistry.

Conflict of interest statement

There are no conflicts to declare.

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