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Fernandez-Fuertes M, Corma-Gomez A, Torres E, et al. Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic. Transbound Emerg Dis. 2021;doi: 10.1111/tbed.14293.
Fernandez-Fuertes, M., Corma-Gomez, A., Torres, E., Rodriguez-Pineda, E., Fuentes-Lopez, A., Rincon, P., Fernandez, N., Garcia, F., Bernal, S., Real, L. M., Macias, J., & Pineda, J. A. (2021). Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic. Transboundary and emerging diseases, . https://doi.org/10.1111/tbed.14293
Fernandez-Fuertes, Marta, et al. "Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic." Transboundary and emerging diseases vol. (2021). doi: https://doi.org/10.1111/tbed.14293
Fernandez-Fuertes M, Corma-Gomez A, Torres E, Rodriguez-Pineda E, Fuentes-Lopez A, Rincon P, Fernandez N, Garcia F, Bernal S, Real LM, Macias J, Pineda JA. Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic. Transbound Emerg Dis. 2021 Aug 17; doi: 10.1111/tbed.14293. Epub 2021 Aug 17. PMID: 34405560; PMCID: PMC8447136.
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Transbound Emerg Dis. 2021 Aug 17; doi: 10.1111/tbed.14293. Epub 2021 Aug 17.

Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic.

Transboundary and emerging diseases

Marta Fernandez-Fuertes, Anaïs Corma-Gomez, Eva Torres, Elena Rodriguez-Pineda, Ana Fuentes-Lopez, Pilar Rincon, Nieves Fernandez, Federico Garcia, Samuel Bernal, Luis M Real, Juan Macias, Juan A Pineda

Affiliations

  1. Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen de Valme, Sevilla, Spain.
  2. Microbiology Service, Hospital Universitario Virgen de Valme, Sevilla, Spain.
  3. Microbiology Service, Hospital Universitario San Cecilio, Granada, Spain.
  4. Department of Surgery, Biochemistry and Immunology, School of Medicine, University of Malaga, Malaga, Spain.
  5. Department of Medicine, School of Medicine, University of Sevilla, Sevilla, Spain.

PMID: 34405560 PMCID: PMC8447136 DOI: 10.1111/tbed.14293

Abstract

Whether people living with HIV (PLWH) are at greater risk of acquiring SARS-CoV-2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS-CoV-2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS-CoV-2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%-9.9%] patients developed SARS-CoV-2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%-9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%-2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS-Cov-2 infection [Incidence rate ratio: 0.29 (95% CI 0.16-0.55) p < .001]. In conclusion, the incidence of SARS-CoV-2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area.

© 2021 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.

Keywords: COVID-19; HIV; SARS-CoV-2 infection; incidence; serum antibodies

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