Display options
Cite
Pandey KN. Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis. Front Physiol. 2021;12:693099doi: 10.3389/fphys.2021.693099.
Pandey, K. N. (2021). Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis. Frontiers in physiology, 12693099. https://doi.org/10.3389/fphys.2021.693099
Pandey, Kailash N. "Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis." Frontiers in physiology vol. 12 (2021): 693099. doi: https://doi.org/10.3389/fphys.2021.693099
Pandey KN. Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis. Front Physiol. 2021 Aug 19;12:693099. doi: 10.3389/fphys.2021.693099. eCollection 2021. PMID: 34489721; PMCID: PMC8416980.
Copy Download .nbib Format: NLM
Share it on

Front Physiol. 2021 Aug 19;12:693099. doi: 10.3389/fphys.2021.693099. eCollection 2021.

Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis.

Frontiers in physiology

Kailash N Pandey

Affiliations

  1. Department of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States.

PMID: 34489721 PMCID: PMC8416980 DOI: 10.3389/fphys.2021.693099

Abstract

The discovery of atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP) and their cognate receptors has greatly increased our knowledge of the control of hypertension and cardiovascular homeostasis. ANP and BNP are potent endogenous hypotensive hormones that elicit natriuretic, diuretic, vasorelaxant, antihypertrophic, antiproliferative, and antiinflammatory effects, largely directed toward the reduction of blood pressure (BP) and cardiovascular diseases (CVDs). The principal receptor involved in the regulatory actions of ANP and BNP is guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), which produces the intracellular second messenger cGMP. Cellular, biochemical, molecular, genetic, and clinical studies have facilitated understanding of the functional roles of natriuretic peptides (NPs), as well as the functions of their receptors, and signaling mechanisms in CVDs. Transgenic and gene-targeting (gene-knockout and gene-duplication) strategies have produced genetically altered novel mouse models and have advanced our knowledge of the importance of NPs and their receptors at physiological and pathophysiological levels in both normal and disease states. The current review describes the past and recent research on the cellular, molecular, genetic mechanisms and functional roles of the ANP-BNP/NPRA system in the physiology and pathophysiology of cardiovascular homeostasis as well as clinical and diagnostic markers of cardiac disorders and heart failure. However, the therapeutic potentials of NPs and their receptors for the diagnosis and treatment of cardiovascular diseases, including hypertension, heart failure, and stroke have just begun to be expanded. More in-depth investigations are needed in this field to extend the therapeutic use of NPs and their receptors to treat and prevent CVDs.

Copyright © 2021 Pandey.

Keywords: cardiovascular disorders; gene-targeting; genetic mouse models; natriuretic peptide receptors; natriuretic peptides

Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Am J Physiol Renal Physiol. 2001 Oct;281(4):F665-73 - PubMed
  2. Peptides. 2005 Jun;26(6):1078-85 - PubMed
  3. Peptides. 2019 Jan;111:18-25 - PubMed
  4. Mol Cell Biochem. 2018 Apr;441(1-2):135-150 - PubMed
  5. J Clin Invest. 2009 Jul;119(7):2019-30 - PubMed
  6. Peptides. 2005 Jun;26(6):985-1000 - PubMed
  7. Endocr Rev. 1994 Apr;15(2):135-62 - PubMed
  8. Mol Pharmacol. 1990 Dec;38(6):771-8 - PubMed
  9. Biochemistry. 1986 Dec 30;25(26):8467-72 - PubMed
  10. J Biol Chem. 1990 Jul 25;265(21):12342-8 - PubMed
  11. Biochem Biophys Res Commun. 2005 Feb 4;327(1):106-11 - PubMed
  12. Curr Cardiol Rep. 2006 Jul;8(4):282-8 - PubMed
  13. Hypertension. 2013 Jul;62(1):147-53 - PubMed
  14. J Clin Invest. 2005 Jun;115(6):1666-74 - PubMed
  15. J Biol Chem. 2003 Jul 11;278(28):25847-52 - PubMed
  16. Kidney Int. 1998 May;53(5):1133-42 - PubMed
  17. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12746-51 - PubMed
  18. J Am Coll Cardiol. 2008 Jul 1;52(1):60-8 - PubMed
  19. Mol Pharmacol. 2003 Sep;64(3):533-46 - PubMed
  20. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5456-61 - PubMed
  21. Am J Physiol Renal Physiol. 2010 Jan;298(1):F103-8 - PubMed
  22. FEBS J. 2016 May;283(9):1767-81 - PubMed
  23. Hypertension. 1992 Jun;19(6 Pt 2):809-13 - PubMed
  24. J Pharmacol Exp Ther. 1992 Oct;263(1):241-5 - PubMed
  25. Biochem Biophys Res Commun. 1989 Dec 15;165(2):650-8 - PubMed
  26. Eur Heart J. 2014 Feb;35(7):419-25 - PubMed
  27. Hypertension. 2005 Aug;46(2):441-7 - PubMed
  28. J Hypertens. 2014 Nov;32(11):2142-3 - PubMed
  29. Cell Signal. 2019 Aug;60:17-30 - PubMed
  30. Science. 1987 Oct 30;238(4827):675-8 - PubMed
  31. Pharmacol Rev. 2000 Sep;52(3):375-414 - PubMed
  32. J Biol Chem. 1991 Jan 5;266(1):136-42 - PubMed
  33. Am J Physiol. 1996 Sep;271(3 Pt 2):F489-97 - PubMed
  34. FEBS J. 2011 Jun;278(11):1818-29 - PubMed
  35. Mol Endocrinol. 1996 Dec;10(12):1719-27 - PubMed
  36. Peptides. 2019 Apr;114:17-28 - PubMed
  37. Circ J. 2014;78(8):1816-23 - PubMed
  38. Eur Heart J. 2020 Mar 1;41(9):1006-1020 - PubMed
  39. J Clin Invest. 1995 Aug;96(2):1093-9 - PubMed
  40. Nat Med. 2004 Jan;10(1):80-6 - PubMed
  41. Kidney Int. 1999 Aug;56(2):502-8 - PubMed
  42. Trends Endocrinol Metab. 2005 Dec;16(10):469-77 - PubMed
  43. Regul Pept. 2009 Feb 25;153(1-3):19-24 - PubMed
  44. J Cell Sci. 2005 Jun 1;118(Pt 11):2495-505 - PubMed
  45. PLoS One. 2012;7(8):e43238 - PubMed
  46. Hypertension. 2018 Aug;72(2):270-276 - PubMed
  47. Am J Physiol Renal Physiol. 2007 Jul;293(1):F121-7 - PubMed
  48. Nature. 1995 Nov 2;378(6552):65-8 - PubMed
  49. JAMA Cardiol. 2018 Jan 1;3(1):7-9 - PubMed
  50. Science. 1989 Jan 20;243(4889):383-5 - PubMed
  51. Science. 1986 Mar 7;231(4742):1145-7 - PubMed
  52. Biomed Res Int. 2014;2014:710781 - PubMed
  53. Am J Physiol. 1984 Apr;246(4 Pt 2):F447-56 - PubMed
  54. Biosci Rep. 2015 Sep 15;35(5): - PubMed
  55. Cardiovasc Res. 2003 Mar;57(3):749-56 - PubMed
  56. Arch Biochem Biophys. 1988 Feb 1;260(2):763-70 - PubMed
  57. JACC Heart Fail. 2019 Oct;7(10):891-898 - PubMed
  58. Front Mol Neurosci. 2014 Aug 22;7:75 - PubMed
  59. Physiol Genomics. 2018 Nov 1;50(11):913-928 - PubMed
  60. Biochem J. 1991 Jun 1;276 ( Pt 2):493-7 - PubMed
  61. FEBS J. 2011 Jun;278(11):1792-807 - PubMed
  62. Klin Wochenschr. 1988 Sep 1;66(17):752-9 - PubMed
  63. Biochem Biophys Res Commun. 1984 Mar 15;119(2):524-9 - PubMed
  64. Int J Physiol Pathophysiol Pharmacol. 2012;4(3):128-39 - PubMed
  65. Ultrasound Obstet Gynecol. 2007 Mar;29(3):296-303 - PubMed
  66. Circ Genom Precis Med. 2019 Aug;12(8):e002472 - PubMed
  67. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2547-51 - PubMed
  68. Endocrinology. 1993 Nov;133(5):2141-9 - PubMed
  69. Endocrinology. 2008 Feb;149(2):483-91 - PubMed
  70. J Nephrol. 2013 Nov-Dec;26(6):1042-8 - PubMed
  71. Int J Mol Sci. 2019 Aug 14;20(16): - PubMed
  72. Mol Cell Biochem. 2013 Jun;378(1-2):217-28 - PubMed
  73. J Clin Invest. 1990 Nov;86(5):1690-7 - PubMed
  74. FASEB J. 2020 Sep;34(9):11925-11943 - PubMed
  75. Annu Rev Biochem. 1991;60:229-55 - PubMed
  76. Cell. 1992 Oct 2;71(1):1-4 - PubMed
  77. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1254-F1272 - PubMed
  78. Am J Physiol. 1988 Nov;255(5 Pt 2):F936-43 - PubMed
  79. Exp Nephrol. 1994 Nov-Dec;2(6):318-23 - PubMed
  80. Physiol Rev. 2002 Jul;82(3):769-824 - PubMed
  81. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4016-21 - PubMed
  82. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F930-7 - PubMed
  83. Biochem Biophys Res Commun. 1988 Sep 15;155(2):726-32 - PubMed
  84. Regul Pept. 2001 May 5;99(1):21-9 - PubMed
  85. Circ Cardiovasc Genet. 2015 Feb;8(1):141-9 - PubMed
  86. Am J Cardiol. 1988 Nov 15;62(16):1122-3 - PubMed
  87. J Biol Chem. 2003 Mar 28;278(13):11159-66 - PubMed
  88. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4862-6 - PubMed
  89. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14730-5 - PubMed
  90. Biochem Biophys Res Commun. 1989 May 15;160(3):1392-6 - PubMed
  91. Lancet. 2010 Apr 10;375(9722):1255-66 - PubMed
  92. J Mol Endocrinol. 2007 Feb;38(1-2):245-57 - PubMed
  93. Biochem Biophys Res Commun. 1993 Feb 15;190(3):724-31 - PubMed
  94. Front Biosci. 2005 May 01;10:1279-89 - PubMed
  95. Circulation. 2002 May 7;105(18):2192-7 - PubMed
  96. Am J Physiol. 1984 Jul;247(1 Pt 2):R34-9 - PubMed
  97. Pharmacol Rev. 1992 Dec;44(4):479-602 - PubMed
  98. Nat Genet. 2009 Mar;41(3):348-53 - PubMed
  99. Clin Sci (Lond). 2008 Jan;114(2):131-7 - PubMed
  100. Am J Physiol. 1995 Jan;268(1 Pt 2):R201-7 - PubMed
  101. Am J Obstet Gynecol. 2009 Mar;200(3):273.e1-273.e25 - PubMed
  102. J Am Coll Cardiol. 2012 Oct 16;60(16):1558-65 - PubMed
  103. Int J Cardiol. 2019 Apr 15;281:166-171 - PubMed
  104. Peptides. 2005 Jun;26(6):944-56 - PubMed
  105. Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L712-9 - PubMed
  106. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H926-34 - PubMed
  107. Mol Cell Biochem. 2002 Apr;233(1-2):165-73 - PubMed
  108. Physiol Genomics. 2016 Jul 1;48(7):477-90 - PubMed
  109. Nature. 2000 Jul 6;406(6791):101-4 - PubMed
  110. Am J Physiol. 1992 Jun;262(6 Pt 2):F911-8 - PubMed
  111. Eur J Heart Fail. 2007 Jun-Jul;9(6-7):548-57 - PubMed
  112. Circulation. 1992 Oct;86(4):1081-8 - PubMed
  113. J Am Coll Cardiol. 2006 Aug 1;48(3):499-505 - PubMed
  114. EMBO J. 1998 Jun 1;17(11):3045-51 - PubMed
  115. Int J Mol Sci. 2019 Apr 28;20(9): - PubMed
  116. J Biol Chem. 2005 May 13;280(19):19230-42 - PubMed
  117. Mol Cell Biochem. 2002 Jan;230(1-2):31-47 - PubMed
  118. Circ Res. 2000 Jun 9;86(11):1135-9 - PubMed
  119. Pharmacol Rev. 1993 Dec;45(4):455-97 - PubMed
  120. Endocrinology. 1993 Dec;133(6):3038-41 - PubMed
  121. Biochem Biophys Res Commun. 2008 Mar 21;367(4):840-5 - PubMed
  122. Physiol Genomics. 2000 Jun 29;3(1):45-58 - PubMed
  123. Endocrinology. 1985 Sep;117(3):1282-4 - PubMed
  124. Circulation. 2002 Sep 24;106(13):1722-8 - PubMed
  125. J Clin Invest. 2012 Mar;122(3):1022-36 - PubMed
  126. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7403-8 - PubMed
  127. Physiol Rev. 1990 Jul;70(3):665-99 - PubMed
  128. J Am Coll Cardiol. 2009 Jun 2;53(22):2070-7 - PubMed
  129. Cardiovasc Res. 2004 Aug 15;63(3):433-42 - PubMed
  130. Am J Physiol. 1984 Nov;247(5 Pt 2):F863-6 - PubMed
  131. Int J Cardiol. 2014 Oct 20;176(3):630-9 - PubMed
  132. Mol Pharmacol. 2000 Feb;57(2):259-67 - PubMed
  133. Hypertension. 2017 Mar;69(3):411-420 - PubMed
  134. Curr Psychiatry Rep. 2008 Aug;10(4):352-8 - PubMed
  135. Circulation. 1996 Jun 1;93(11):1963-9 - PubMed
  136. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6828-31 - PubMed
  137. Cardiovasc Ther. 2011 Dec;29(6):362-76 - PubMed
  138. Biochim Biophys Acta. 1997 Apr 24;1356(2):221-8 - PubMed
  139. Circ Res. 2000 Apr 28;86(8):841-5 - PubMed
  140. Am J Physiol. 1985 Apr;248(4 Pt 2):R495-500 - PubMed
  141. Science. 2001 Aug 31;293(5535):1657-62 - PubMed
  142. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4735-40 - PubMed
  143. Science. 1984 Jun 1;224(4652):992-4 - PubMed
  144. J Clin Invest. 1996 Dec 15;98(12):2854-65 - PubMed
  145. Hypertension. 1997 Jan;29(1 Pt 2):414-21 - PubMed
  146. J Cardiol. 2010 Nov;56(3):262-70 - PubMed
  147. Heart. 2005 Jul;91(7):926-31 - PubMed
  148. Int J Mol Sci. 2019 Feb 13;20(4): - PubMed
  149. Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R257-65 - PubMed
  150. Circ Res. 2001 Feb 2;88(2):223-8 - PubMed
  151. Clin Exp Pharmacol Physiol. 1997 May;24(5):374-6 - PubMed
  152. Endocrinology. 2010 Dec;151(12):5841-50 - PubMed
  153. Biochem J. 1992 Nov 15;288 ( Pt 1):55-61 - PubMed
  154. Cardiovasc Res. 1999 Aug 1;43(2):437-44 - PubMed
  155. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R104-14 - PubMed
  156. J Clin Invest. 2012 Dec;122(12):4675-9 - PubMed
  157. Diabetes. 2008 Dec;57(12):3199-204 - PubMed
  158. N Engl J Med. 2000 Jul 27;343(4):246-53 - PubMed
  159. J Biol Chem. 2003 Oct 3;278(40):38693-8 - PubMed
  160. Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F68-84 - PubMed
  161. BMJ. 2005 Mar 19;330(7492):625 - PubMed
  162. Mol Cell Biochem. 2007 Jul;301(1-2):93-107 - PubMed
  163. Eur J Heart Fail. 2004 Mar 15;6(3):351-4 - PubMed
  164. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):645-9 - PubMed
  165. Pharmacol Ther. 2014 Oct;144(1):12-27 - PubMed
  166. J Biol Chem. 1992 Jun 15;267(17):11987-94 - PubMed
  167. J Clin Invest. 1992 Sep;90(3):1145-9 - PubMed
  168. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13789-94 - PubMed
  169. Circulation. 2003 Feb 18;107(6):831-7 - PubMed
  170. Biochemistry. 1999 Dec 21;38(51):16941-51 - PubMed
  171. Hypertension. 2014 Mar;63(3):514-9 - PubMed
  172. Hypertension. 1995 Dec;26(6 Pt 1):847-53 - PubMed
  173. Mol Cell Biochem. 2010 Jan;334(1-2):81-98 - PubMed
  174. J Am Soc Hypertens. 2008 Jul-Aug;2(4):210-26 - PubMed
  175. J Clin Invest. 1987 Feb;79(2):500-7 - PubMed
  176. Diabetes. 2015 Dec;64(12):4033-45 - PubMed
  177. Clin Exp Pharmacol Physiol. 2010 Feb;37(2):e70-7 - PubMed
  178. Eur J Clin Pharmacol. 1986;31(1):101-3 - PubMed
  179. J Biol Chem. 1994 Oct 21;269(42):26227-33 - PubMed
  180. Crit Care Clin. 2006 Jul;22(3):503-19, ix-x - PubMed
  181. Proc Assoc Am Physicians. 1999 Sep-Oct;111(5):406-16 - PubMed
  182. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F781-F795 - PubMed
  183. J Biol Chem. 2003 Nov 28;278(48):47694-9 - PubMed
  184. Circulation. 1993 Jan;87(1):70-5 - PubMed
  185. FEBS J. 2011 Jun;278(11):1830-41 - PubMed
  186. Circulation. 2003 Aug 12;108(6):638-40 - PubMed
  187. Endocrinology. 2014 Mar;155(3):1045-56 - PubMed
  188. Life Sci. 1981 Jan 5;28(1):89-94 - PubMed
  189. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17300-5 - PubMed
  190. Mol Cell Biochem. 2012 Sep;368(1-2):47-59 - PubMed
  191. Am J Cardiol. 2006 May 15;97(10):1530-4 - PubMed
  192. Hypertension. 1990 Sep;16(3):301-7 - PubMed
  193. J Clin Invest. 1991 Apr;87(4):1402-12 - PubMed
  194. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H707-14 - PubMed
  195. Biochim Biophys Acta. 2009 Dec;1792(12):1175-84 - PubMed
  196. Circulation. 1991 Oct;84(4):1581-8 - PubMed
  197. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1516-21 - PubMed
  198. Nature. 1989 Mar 2;338(6210):78-83 - PubMed
  199. Kidney Int Suppl. 1996 Jun;55:S144-7 - PubMed
  200. Biochem J. 2005 May 15;388(Pt 1):103-13 - PubMed
  201. J Clin Invest. 1994 May;93(5):1911-21 - PubMed
  202. Biochem Biophys Res Commun. 1985 Dec 17;133(2):800-6 - PubMed
  203. J Clin Invest. 1995 Mar;95(3):1101-8 - PubMed
  204. J Investig Med. 2009 Jan;57(1):18-21 - PubMed
  205. Am J Physiol. 1990 Sep;259(3 Pt 1):E312-8 - PubMed
  206. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4239-44 - PubMed
  207. N Engl J Med. 2014 Sep 11;371(11):993-1004 - PubMed
  208. J Biol Chem. 2002 Feb 15;277(7):4618-27 - PubMed
  209. J Clin Endocrinol Metab. 1993 Jan;76(1):91-6 - PubMed
  210. J Mol Cell Cardiol. 1996 Aug;28(8):1811-5 - PubMed
  211. Heart. 2013 May;99(10):677-9 - PubMed
  212. J Biol Chem. 1988 Jul 5;263(19):9395-401 - PubMed
  213. J Biol Chem. 1992 Jul 15;267(20):13928-32 - PubMed
  214. J Biol Chem. 2014 Mar 7;289(10):6991-7002 - PubMed
  215. Curr Opin Nephrol Hypertens. 1996 Jan;5(1):4-11 - PubMed
  216. Cell Metab. 2010 Apr 7;11(4):248-52 - PubMed
  217. Life Sci. 1986 May 19;38(20):1827-33 - PubMed
  218. Science. 1991 Apr 5;252(5002):120-3 - PubMed
  219. Am J Physiol Renal Physiol. 2003 Oct;285(4):F694-702 - PubMed
  220. J Clin Invest. 2003 May;111(9):1399-407 - PubMed
  221. Heart. 2006 Jan;92(1):121-3 - PubMed
  222. Int J Mol Sci. 2019 Jul 02;20(13): - PubMed
  223. Peptides. 2005 Jun;26(6):901-32 - PubMed
  224. Int J Cardiol. 2019 Apr 15;281:186-189 - PubMed
  225. Circ Res. 2003 Aug 22;93(4):280-91 - PubMed
  226. Circulation. 1993 Jul;88(1):82-91 - PubMed
  227. Br Heart J. 1989 Feb;61(2):139-43 - PubMed
  228. J Biol Chem. 1993 Feb 25;268(6):4382-90 - PubMed
  229. J Biol Chem. 1988 Sep 15;263(26):13406-13 - PubMed
  230. Science. 1995 Feb 3;267(5198):679-81 - PubMed
  231. Endocrinology. 2007 Sep;148(9):4162-9 - PubMed
  232. J Biol Chem. 1984 Dec 10;259(23):14332-4 - PubMed
  233. J Biol Chem. 1988 Mar 15;263(8):3720-8 - PubMed
  234. N Engl J Med. 2002 Jul 18;347(3):161-7 - PubMed
  235. Biochem Biophys Res Commun. 1993 Aug 31;195(1):72-8 - PubMed
  236. Pflugers Arch. 1996 Feb;431(4):571-7 - PubMed
  237. Physiol Genomics. 2007 Oct 22;31(2):193-202 - PubMed
  238. Circulation. 2004 Feb 10;109(5):594-600 - PubMed
  239. Am J Physiol. 1991 Dec;261(6 Pt 2):F921-32 - PubMed
  240. J Pharmacol Exp Ther. 1992 Feb;260(2):825-31 - PubMed
  241. Peptides. 2005 Jun;26(6):957-68 - PubMed
  242. Trends Endocrinol Metab. 2006 Aug;17(6):251-8 - PubMed
  243. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6697-701 - PubMed
  244. Am J Physiol. 1992 Jun;262(6 Pt 2):H1861-6 - PubMed
  245. Am J Physiol. 1990 Nov;259(5 Pt 2):F832-8 - PubMed
  246. Science. 1985 Nov 15;230(4727):767-70 - PubMed
  247. Sci Rep. 2020 Mar 9;10(1):4337 - PubMed
  248. CMAJ. 2006 Sep 12;175(6):611-7 - PubMed
  249. J Clin Invest. 2001 Apr;107(8):975-84 - PubMed
  250. J Clin Endocrinol Metab. 1994 Jun;78(6):1428-35 - PubMed
  251. Int J Biochem Mol Biol. 2013 Mar 31;4(1):41-53 - PubMed
  252. J Hypertens. 2013 Jan;31(1):134-44 - PubMed
  253. Am J Physiol. 1986 Jun;250(6 Pt 2):F963-6 - PubMed
  254. Circ Res. 2021 Jan 8;128(1):115-129 - PubMed
  255. Peptides. 2005 Jun;26(6):1024-34 - PubMed
  256. Heart. 2006 Jun;92(6):843-9 - PubMed
  257. N Engl J Med. 1998 Jul 30;339(5):321-8 - PubMed
  258. J Am Coll Cardiol. 1996 Oct;28(4):964-71 - PubMed
  259. Diabetes. 2009 Dec;58(12):2880-92 - PubMed
  260. Nature. 1984 Jun 21-27;309(5970):722-4 - PubMed
  261. Biochimie. 2016 May;124:84-91 - PubMed
  262. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1712-20 - PubMed
  263. EMBO J. 1989 May;8(5):1377-84 - PubMed
  264. Circ J. 2005 Mar;69(3):283-90 - PubMed
  265. Can J Physiol Pharmacol. 2001 Aug;79(8):705-14 - PubMed
  266. Circulation. 2007 Mar 20;115(11):1345-53 - PubMed
  267. J Am Coll Cardiol. 2006 Jul 4;48(1):1-11 - PubMed
  268. J Cardiovasc Pharmacol. 1998;32 Suppl 3:S22-8 - PubMed

Publication Types

Grant support