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Ukraintseva S, Duan M, Arbeev K, et al. Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation. Front Cell Dev Biol. 2021;9:692020doi: 10.3389/fcell.2021.692020.
Ukraintseva, S., Duan, M., Arbeev, K., Wu, D., Bagley, O., Yashkin, A. P., Gorbunova, G., Akushevich, I., Kulminski, A., & Yashin, A. (2021). Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation. Frontiers in cell and developmental biology, 9692020. https://doi.org/10.3389/fcell.2021.692020
Ukraintseva, Svetlana, et al. "Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation." Frontiers in cell and developmental biology vol. 9 (2021): 692020. doi: https://doi.org/10.3389/fcell.2021.692020
Ukraintseva S, Duan M, Arbeev K, Wu D, Bagley O, Yashkin AP, Gorbunova G, Akushevich I, Kulminski A, Yashin A. Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation. Front Cell Dev Biol. 2021 Aug 19;9:692020. doi: 10.3389/fcell.2021.692020. eCollection 2021. PMID: 34490245; PMCID: PMC8417405.
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Front Cell Dev Biol. 2021 Aug 19;9:692020. doi: 10.3389/fcell.2021.692020. eCollection 2021.

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.

Frontiers in cell and developmental biology

Svetlana Ukraintseva, Matt Duan, Konstantin Arbeev, Deqing Wu, Olivia Bagley, Arseniy P Yashkin, Galina Gorbunova, Igor Akushevich, Alexander Kulminski, Anatoliy Yashin

Affiliations

  1. Biodemography of Aging Research Unit, Duke University, Durham, NC, United States.

PMID: 34490245 PMCID: PMC8417405 DOI: 10.3389/fcell.2021.692020

Abstract

A major goal of aging research is identifying genetic targets that could be used to slow or reverse aging - changes in the body and extend limits of human lifespan. However, majority of genes that showed the anti-aging and pro-survival effects in animal models were not replicated in humans, with few exceptions. Potential reasons for this lack of translation include a highly conditional character of genetic influence on lifespan, and its heterogeneity, meaning that better survival may be result of not only activity of individual genes, but also gene-environment and gene-gene interactions, among other factors. In this paper, we explored associations of genetic interactions with human lifespan. We selected candidate genes from well-known aging pathways (IGF1/FOXO growth signaling, P53/P16 apoptosis/senescence, and mTOR/SK6 autophagy and survival) that jointly decide on outcomes of cell responses to stress and damage, and so could be prone to interactions. We estimated associations of pairwise statistical epistasis between SNPs in these genes with survival to age 85+ in the Atherosclerosis Risk in Communities study, and found significant (FDR < 0.05) effects of interactions between SNPs in

Copyright © 2021 Ukraintseva, Duan, Arbeev, Wu, Bagley, Yashkin, Gorbunova, Akushevich, Kulminski and Yashin.

Keywords: aging genes; aging pathways; animal to human translation; genetic interactions; heterogeneity of longevity; human lifespan; statistical epistasis; stress response

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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