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Osório LA, Silva E, Mackay RE. A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems. Bioengineering (Basel). 2021;8(8)doi: 10.3390/bioengineering8080113.
Osório, L. A., Silva, E., & Mackay, R. E. (2021). A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems. Bioengineering (Basel, Switzerland), 8(8), . https://doi.org/10.3390/bioengineering8080113
Osório, Luana A, et al. "A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems." Bioengineering (Basel, Switzerland) vol. 8,8 (2021). doi: https://doi.org/10.3390/bioengineering8080113
Osório LA, Silva E, Mackay RE. A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems. Bioengineering (Basel). 2021 Aug 06;8(8). doi: 10.3390/bioengineering8080113. PMID: 34436116; PMCID: PMC8389238.
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Bioengineering (Basel). 2021 Aug 06;8(8). doi: 10.3390/bioengineering8080113.

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems.

Bioengineering (Basel, Switzerland)

Luana A Osório, Elisabete Silva, Ruth E Mackay

Affiliations

  1. Department of Mechanical, Aerospace and Civil Engineering, Brunel University London, Uxbridge UB8 3PH, UK.
  2. Department of Life Science, Brunel University London, Uxbridge UB8 3PH, UK.

PMID: 34436116 PMCID: PMC8389238 DOI: 10.3390/bioengineering8080113

Abstract

Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with results from later human clinical trials. Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems, which recapitulate the physiochemical environment of a specific organ by emulating the perfusion and shear stress cellular tissue undergoes in vivo and could replace current animal models. The success of culturing cells and cell-derived tissues within these systems is dependent on the scaffold chosen; hence, scaffolds are critical for the success of OOACs in research. A literature review was conducted looking at current OOAC systems to assess the advantages and disadvantages of different materials and manufacturing techniques used for scaffold production; and the alternatives that could be tailored from the macro tissue engineering research field.

Keywords: additive manufacturing; biomaterials; organ-on-a-chip; scaffold; tissue engineering

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