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Kenwood BM, McLoughlin C, Zhang L, et al. Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Biomarkers. 2021;26(7):656-664doi: 10.1080/1354750X.2021.1970809.
Kenwood, B. M., McLoughlin, C., Zhang, L., Zhu, W., Bhandari, D., De Jesús, V. R., & Blount, B. C. (2021). Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 26(7), 656-664. https://doi.org/10.1080/1354750X.2021.1970809
Kenwood, Brandon M, et al. "Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016." Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals vol. 26,7 (2021): 656-664. doi: https://doi.org/10.1080/1354750X.2021.1970809
Kenwood BM, McLoughlin C, Zhang L, Zhu W, Bhandari D, De Jesús VR, Blount BC. Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Biomarkers. 2021 Nov;26(7):656-664. doi: 10.1080/1354750X.2021.1970809. Epub 2021 Sep 02. PMID: 34409911; PMCID: PMC8517914.
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Biomarkers. 2021 Nov;26(7):656-664. doi: 10.1080/1354750X.2021.1970809. Epub 2021 Sep 02.

Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Brandon M Kenwood, Caitlyn McLoughlin, Luyu Zhang, Wanzhe Zhu, Deepak Bhandari, Víctor R De Jesús, Benjamin C Blount

Affiliations

  1. Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

PMID: 34409911 PMCID: PMC8517914 DOI: 10.1080/1354750X.2021.1970809

Abstract

BACKGROUND: 2-Hydroxyethyl mercapturic acid (2HEMA, N-acetyl-S-(2-hydroxyethyl)-L-cysteine) is a urinary metabolite of several volatile organic compounds including acrylonitrile and ethylene oxide, which are found in cigarette smoke.

METHODS: We measured 2HEMA concentrations in urine specimens collected during the National Health and Nutrition Examination Survey (2011-2016) from eligible participants aged >12 years (

RESULTS: We detected 2HEMA in 85% of samples tested among exclusive cigarette smokers, and only 40% of specimens from non-smokers. When compared to exclusive cigarette smokers who smoked 1-9 CPD, smoking 10-19 CPD was associated with 36% higher 2HEMA (

CONCLUSIONS: This study demonstrates that cigarette smoking intensity is associated with higher urinary 2HEMA concentrations and is likely a major source of acrylonitrile and/or ethylene oxide exposure.

Keywords: N-acetyl-S-(2-hydroxyethyl)-L-cysteine; acrylonitrile; biomonitoring; ethylene oxide; tobacco smoke exposure; vinyl chloride

References

  1. Int Arch Occup Environ Health. 1998 Oct;71(7):499-502 - PubMed
  2. Regul Toxicol Pharmacol. 2007 Mar;47(2):171-83 - PubMed
  3. Stat Med. 2008 Sep 10;27(20):4094-106 - PubMed
  4. Environ Res. 2019 Apr;171:101-110 - PubMed
  5. Carcinogenesis. 1986 Sep;7(9):1519-21 - PubMed
  6. JAMA. 1996 Apr 24;275(16):1233-40 - PubMed
  7. Anal Bioanal Chem. 2015 Jul;407(18):5463-76 - PubMed
  8. Toxicol Mech Methods. 2018 Jun;28(5):386-396 - PubMed
  9. J Toxicol Environ Health B Crit Rev. 2021 Jan 2;24(1):1-29 - PubMed
  10. Carcinogenesis. 1996 Dec;17(12):2655-60 - PubMed
  11. Environ Sci Technol. 2020 Feb 18;54(4):2370-2378 - PubMed
  12. Chem Res Toxicol. 2009 Apr;22(4):734-41 - PubMed
  13. Nicotine Tob Res. 2016 Sep;18(9):1886-94 - PubMed
  14. Carcinogenesis. 1994 Jun;15(6):1271-4 - PubMed
  15. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:197-205 - PubMed
  16. Chem Res Toxicol. 1997 Jan;10(1):78-84 - PubMed
  17. Int Arch Occup Environ Health. 1991;63(1):27-31 - PubMed
  18. Chem Res Toxicol. 2011 Nov 21;24(11):1957-65 - PubMed
  19. Environ Sci Pollut Res Int. 2021 Apr;28(13):16781-16791 - PubMed
  20. J Expo Anal Environ Epidemiol. 1999 Jul-Aug;9(4):336-42 - PubMed
  21. Analyst. 1998 May;123(5):1095-101 - PubMed
  22. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:102-9 - PubMed
  23. Chem Res Toxicol. 2001 Jul;14(7):767-90 - PubMed
  24. Regul Toxicol Pharmacol. 2008 Dec;52(3):342-51 - PubMed
  25. Int J Environ Res Public Health. 2020 Nov 21;17(22): - PubMed
  26. Environ Health Perspect. 2005 Feb;113(2):192-200 - PubMed
  27. PLoS One. 2019 Jan 4;14(1):e0210104 - PubMed
  28. J Anal Toxicol. 2009 Jan-Feb;33(1):1-7 - PubMed
  29. Mutat Res. 1991 Sep-Oct;250(1-2):483-97 - PubMed
  30. Environ Res. 1999 Jul;81(1):62-71 - PubMed
  31. Nicotine Tob Res. 2020 Oct 8;22(10):1744-1747 - PubMed
  32. Int J Environ Res Public Health. 2019 Dec 19;17(1): - PubMed
  33. J Expo Sci Environ Epidemiol. 2021 Mar;31(2):377-385 - PubMed
  34. Regul Toxicol Pharmacol. 2005 Oct;43(1):85-103 - PubMed
  35. Biomarkers. 2021 Jun;26(4):371-383 - PubMed
  36. Int J Environ Res Public Health. 2020 Jul 28;17(15): - PubMed
  37. Environ Res. 2018 May;163:1-9 - PubMed
  38. Sci Total Environ. 2014 Feb 15;472:72-7 - PubMed
  39. Am J Epidemiol. 2009 Jan 15;169(2):236-48 - PubMed
  40. J Expo Anal Environ Epidemiol. 2005 Jan;15(1):66-73 - PubMed
  41. Int Arch Occup Environ Health. 1995;67(4):237-42 - PubMed
  42. Clin Chim Acta. 2010 Aug 5;411(15-16):1063-8 - PubMed
  43. J Carcinog. 2012;11:5 - PubMed
  44. Anal Chim Acta. 2012 Oct 31;750:152-60 - PubMed
  45. Arch Toxicol. 1989;63(3):173-84 - PubMed
  46. Arch Toxicol. 1992;66(3):157-63 - PubMed
  47. Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):705-12 - PubMed
  48. Environ Toxicol Pharmacol. 2015 Sep;40(2):471-9 - PubMed
  49. Toxicol Lett. 2002 Aug 5;134(1-3):65-70 - PubMed
  50. Am J Infect Control. 2007 Nov;35(9):574-81 - PubMed

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