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Jimenez Castro PD, Venkatesan A, Redman E, et al. Multiple drug resistance in hookworms infecting greyhound dogs in the USA. Int J Parasitol Drugs Drug Resist. 2021;17:107-117doi: 10.1016/j.ijpddr.2021.08.005.
Jimenez Castro, P. D., Venkatesan, A., Redman, E., Chen, R., Malatesta, A., Huff, H., Zuluaga Salazar, D. A., Avramenko, R., Gilleard, J. S., & Kaplan, R. M. (2021). Multiple drug resistance in hookworms infecting greyhound dogs in the USA. International journal for parasitology. Drugs and drug resistance, 17107-117. https://doi.org/10.1016/j.ijpddr.2021.08.005
Jimenez Castro, Pablo D, et al. "Multiple drug resistance in hookworms infecting greyhound dogs in the USA." International journal for parasitology. Drugs and drug resistance vol. 17 (2021): 107-117. doi: https://doi.org/10.1016/j.ijpddr.2021.08.005
Jimenez Castro PD, Venkatesan A, Redman E, Chen R, Malatesta A, Huff H, Zuluaga Salazar DA, Avramenko R, Gilleard JS, Kaplan RM. Multiple drug resistance in hookworms infecting greyhound dogs in the USA. Int J Parasitol Drugs Drug Resist. 2021 Sep 02;17:107-117. doi: 10.1016/j.ijpddr.2021.08.005. Epub 2021 Sep 02. PMID: 34492564; PMCID: PMC8426179.
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Int J Parasitol Drugs Drug Resist. 2021 Sep 02;17:107-117. doi: 10.1016/j.ijpddr.2021.08.005. Epub 2021 Sep 02.

Multiple drug resistance in hookworms infecting greyhound dogs in the USA.

International journal for parasitology. Drugs and drug resistance

Pablo D Jimenez Castro, Abhinaya Venkatesan, Elizabeth Redman, Rebecca Chen, Abigail Malatesta, Hannah Huff, Daniel A Zuluaga Salazar, Russell Avramenko, John S Gilleard, Ray M Kaplan

Affiliations

  1. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA; Grupo de Parasitología Veterinaria, Universidad Nacional de Colombia, Colombia. Electronic address: [email protected].
  2. Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, Host-Parasite Interactions Program, University of Calgary, Alberta, Canada.
  3. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.
  4. Laboratorio de Parasitología Veterinaria, Corporación Universitaria Santa Rosa de Cabal-UNISARC, Santa Rosa de Cabal, Risaralda, Colombia.

PMID: 34492564 PMCID: PMC8426179 DOI: 10.1016/j.ijpddr.2021.08.005

Abstract

Ancylostoma caninum is the most prevalent nematode parasite of dogs. We confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the USA. Cases of MDR hookworms appear to be highly overrepresented in greyhounds. The aims of this study were to evaluate the drug-resistant phenotypes and genotypes of the A. caninum infecting greyhounds. Fecal samples from greyhounds of the USA were acquired from two greyhound adoption kennels, one active greyhound racing kennel, and three veterinary practices. Fecal egg counts (FECs) were performed on fecal samples from 219 greyhounds, and despite treatment with anthelmintics, the mean FEC was 822.4 eggs per gram (EPG). Resistance to benzimidazoles and macrocyclic lactones were measured using the egg hatch assay (EHA) and the larval development assay (LDA), respectively. We performed 23 EHA and 22 LDA on either individual or pooled feces, representing 54 animals. Mean and median IC

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: Ancylostoma caninum, hookworms; Deep-amplicon; Greyhounds; Multiple-drug resistance (MDR)

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