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Lundquist LR, Rasmussen B, Waldorff FB, et al. Predictors of health-related quality of life in patients with Crohn's disease receiving biological therapy. Scand J Gastroenterol. 2021;56(12):1434-1441doi: 10.1080/00365521.2021.1974086.
Lundquist, L. R., Rasmussen, B., Waldorff, F. B., Wehberg, S., Kjeldsen, J., & Haastrup, P. (2021). Predictors of health-related quality of life in patients with Crohn's disease receiving biological therapy. Scandinavian journal of gastroenterology, 56(12), 1434-1441. https://doi.org/10.1080/00365521.2021.1974086
Lundquist, Lasse R, et al. "Predictors of health-related quality of life in patients with Crohn's disease receiving biological therapy." Scandinavian journal of gastroenterology vol. 56,12 (2021): 1434-1441. doi: https://doi.org/10.1080/00365521.2021.1974086
Lundquist LR, Rasmussen B, Waldorff FB, Wehberg S, Kjeldsen J, Haastrup P. Predictors of health-related quality of life in patients with Crohn's disease receiving biological therapy. Scand J Gastroenterol. 2021 Dec;56(12):1434-1441. doi: 10.1080/00365521.2021.1974086. Epub 2021 Sep 07. PMID: 34493132.
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Scand J Gastroenterol. 2021 Dec;56(12):1434-1441. doi: 10.1080/00365521.2021.1974086. Epub 2021 Sep 07.

Predictors of health-related quality of life in patients with Crohn's disease receiving biological therapy.

Scandinavian journal of gastroenterology

Lasse R Lundquist, Bjørn Rasmussen, Frans Boch Waldorff, Sonja Wehberg, Jens Kjeldsen, Peter Haastrup

Affiliations

  1. Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  2. Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  3. Department of Medical Gastroenterology S, Odense University Hospital, Odense, Denmark.
  4. Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

PMID: 34493132 DOI: 10.1080/00365521.2021.1974086

Abstract

BACKGROUND AND AIM: Health-related quality of life (HRQoL) is impaired in patients with Crohn's disease (CD). This study aimed to identify the impact of clinical disease activity on HRQoL in CD patients treated with biological agents.

METHODS: Patients with moderate to severe active CD treated with biological agents in Denmark were included from 2016-2018. Disease related symptoms were assessed

RESULTS: In total, 1,181 CD patients were included. The mean age was 33 years and 56% were women. Abdominal pain (range of regression coefficients 1.18-1.42), number of liquid stools (0.33-0.58), and the appearance of a new rectal fistula (0.91-1.32) affected all domains in the SHS negatively for men and women. Arthralgia (0.47-0.67) and abdominal mass (0.54-0.62) affected 4 out of 5 items on SHS negatively for women and men, respectively. Female sex was found a predictor of lower HRQoL across all SHS items, whereas age and fistulizing disease, as phenotype, were not associated with lower HRQoL.

CONCLUSIONS: Abdominal pain, number of liquid stools, a new rectal fistula, arthralgia for women, clinically assessed abdominal mass for men as well as female sex, were all found to be predictors of decreased HRQoL.

Keywords: Crohn’s disease; Harvey Bradshaw index; Health-related quality of life; biological treatment; clinical activity indices; epidemiology; short health scale

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