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Calcaterra V, De Silvestri A, Schneider L, et al. Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight. Children (Basel). 2021;8(8)doi: 10.3390/children8080710.
Calcaterra, V., De Silvestri, A., Schneider, L., Acunzo, M., Vittoni, V., Meraviglia, G., Bergamaschi, F., Zuccotti, G., & Mameli, C. (2021). Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight. Children (Basel, Switzerland), 8(8), . https://doi.org/10.3390/children8080710
Calcaterra, Valeria, et al. "Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight." Children (Basel, Switzerland) vol. 8,8 (2021). doi: https://doi.org/10.3390/children8080710
Calcaterra V, De Silvestri A, Schneider L, Acunzo M, Vittoni V, Meraviglia G, Bergamaschi F, Zuccotti G, Mameli C. Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight. Children (Basel). 2021 Aug 18;8(8). doi: 10.3390/children8080710. PMID: 34438601; PMCID: PMC8391689.
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Children (Basel). 2021 Aug 18;8(8). doi: 10.3390/children8080710.

Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight.

Children (Basel, Switzerland)

Valeria Calcaterra, Annalisa De Silvestri, Laura Schneider, Miriam Acunzo, Viola Vittoni, Giulia Meraviglia, Francesco Bergamaschi, Gianvincenzo Zuccotti, Chiara Mameli

Affiliations

  1. Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
  2. Department of Pediatrics, Children's Hospital "Vittore Buzzi", 20154 Milan, Italy.
  3. Biometry & Clinical Epidemiology, Scientific Direction, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
  4. Department of Biomedical and Clinical Science, "Luigi Sacco", University of Milano, 20142 Milano, Italy.
  5. Pediatric Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.

PMID: 34438601 PMCID: PMC8391689 DOI: 10.3390/children8080710

Abstract

Acanthosis nigricans (AN) is associated with obesity and type 2 diabetes, where insulin resistance (IR) is considered a predisposing factor. IR can also affect patients with type 1 diabetes (T1D). We evaluated the prevalence of AN in patients with T1D compared to subjects with obesity in order to define the interplay between IR and excess weight. We considered 138 pediatric patients who presented with T1D and 162 with obesity. As controls, 100 healthy normal-weight subjects were included. A physical examination with the detection of AN and biochemical assessments was performed. IR was calculated by using the homeostasis model assessment for IR in patients with obesity and the estimated glucose disposal rate in T1D. The AN prevalence was higher in T1D and obese subjects compared with controls in whom AN was not detected (

Keywords: acanthosis nigricans; adolescents; children; insulin resistance; obesity; type 1 diabetes

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