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Xin JW, Chai ZX, Zhang CF, et al. Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation. J Anim Physiol Anim Nutr (Berl). 2021;doi: 10.1111/jpn.13629.
Xin, J. W., Chai, Z. X., Zhang, C. F., Zhang, Q., Zhu, Y., Cao, H. W., YangJi, C., Chen, X. Y., Jiang, H., Zhong, J. C., & Ji, Q. M. (2021). Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation. Journal of animal physiology and animal nutrition, . https://doi.org/10.1111/jpn.13629
Xin, Jin-Wei, et al. "Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation." Journal of animal physiology and animal nutrition vol. (2021). doi: https://doi.org/10.1111/jpn.13629
Xin JW, Chai ZX, Zhang CF, Zhang Q, Zhu Y, Cao HW, YangJi C, Chen XY, Jiang H, Zhong JC, Ji QM. Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation. J Anim Physiol Anim Nutr (Berl). 2021 Sep 08; doi: 10.1111/jpn.13629. Epub 2021 Sep 08. PMID: 34494310.
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J Anim Physiol Anim Nutr (Berl). 2021 Sep 08; doi: 10.1111/jpn.13629. Epub 2021 Sep 08.

Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation.

Journal of animal physiology and animal nutrition

Jin-Wei Xin, Zhi-Xin Chai, Cheng-Fu Zhang, Qiang Zhang, Yong Zhu, Han-Wen Cao, Cidan YangJi, Xiao-Ying Chen, Hui Jiang, Jin-Cheng Zhong, Qiu-Mei Ji

Affiliations

  1. State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement, Lhasa, China.
  2. Institute of Animal Science and Veterinary, Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, China.
  3. Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, China.

PMID: 34494310 DOI: 10.1111/jpn.13629

Abstract

Yaks display unique properties of the lung and heart, enabling their adaptation to high-altitude environments, but the underlying molecular mechanisms are still largely unknown. In the present study, the proteome differences in lung and heart tissues were compared between yak (Bos grunniens) and three cattle strains (Bos taurus, Holstein, Sanjiang and Tibetan cattle) using the sequential window acquisition of all theoretical mass spectra/data-independent acquisition (SWATH/DIA) proteomic method. In total, 51,755 peptides and 7215 proteins were identified. In the lung tissue, there were 162, 310 and 118 differential abundance proteins (DAPs) in Tibetan, Holstein and Sanjiang cattle compared to yak respectively. In the heart tissue, there were 71, 57 and 78 DAPs in Tibetan, Holstein and Sanjiang cattle compared to yak respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that the DAPs were enriched for the retinol metabolism and toll-like receptor categories in lung tissue. The changes in these two pathways may regulate hypoxia-induced factor and immune function in yaks. Moreover, DAPs in heart tissues were enriched for cardiac muscle contraction, Huntington's disease, chemical carcinogenesis and drug metabolism-cytochrome P450. Further exploration indicated that yaks may alter cardiac function through regulation of type 2 ryanodine receptor (RyR2) and Ca

© 2021 Wiley-VCH GmbH.

Keywords: cardiac muscle contraction; high-altitude adaptation; retinol metabolism; toll-like receptor; yak

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