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Wei YX, Liu BP, Qiu HM, et al. Effects of vitamin D-related gene polymorphisms on attempted suicide. Psychiatr Genet. 2021;31(6):230-238doi: 10.1097/YPG.0000000000000295.
Wei, Y. X., Liu, B. P., Qiu, H. M., Zhang, J. Y., Wang, X. T., & Jia, C. X. (2021). Effects of vitamin D-related gene polymorphisms on attempted suicide. Psychiatric genetics, 31(6), 230-238. https://doi.org/10.1097/YPG.0000000000000295
Wei, Yan-Xin, et al. "Effects of vitamin D-related gene polymorphisms on attempted suicide." Psychiatric genetics vol. 31,6 (2021): 230-238. doi: https://doi.org/10.1097/YPG.0000000000000295
Wei YX, Liu BP, Qiu HM, Zhang JY, Wang XT, Jia CX. Effects of vitamin D-related gene polymorphisms on attempted suicide. Psychiatr Genet. 2021 Dec 01;31(6):230-238. doi: 10.1097/YPG.0000000000000295. PMID: 34412081.
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Psychiatr Genet. 2021 Dec 01;31(6):230-238. doi: 10.1097/YPG.0000000000000295.

Effects of vitamin D-related gene polymorphisms on attempted suicide.

Psychiatric genetics

Yan-Xin Wei, Bao-Peng Liu, Hui-Min Qiu, Ji-Yu Zhang, Xin-Ting Wang, Cun-Xian Jia

Affiliations

  1. Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University.
  2. Shandong University Center for Suicide Prevention Research.
  3. Department of Psychology, Shandong Provincial Center for Mental Health.
  4. Department of Business Management, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, China.

PMID: 34412081 DOI: 10.1097/YPG.0000000000000295

Abstract

OBJECTIVE: Emerging evidence suggests that vitamin D might protect from attempted suicide. The study aimed to investigate the associations between single-nucleotide polymorphisms (SNPs) related to vitamin D levels identified in a large genome-wide association study and attempted suicide in rural China.

METHODS: This 1:1 matched case-control study included altogether 510 suicide attempters and 510 community controls. Genotypes of four target SNPs (DHCR7-rs12785878, CYP2R1-rs10741657, GC-rs2282679, and CYP24A1-rs6013897) were determined, and a genetic risk score (GRS) was constructed to evaluate the combined effect of them. Demographic and psychological information was acquired through face-to-face interviews.

RESULTS: The A allele of CYP24A1-rs6013897 was significantly associated with attempted suicide (OR = 1.27, 95% CI, 1.03-1.58, P = 0.029), even after adjusting for demographic and psychological confounders (adjusted OR = 1.53, 95% CI, 1.01-2.30, P = 0.043). The GRS analyses revealed a significantly higher risk of attempted suicide with a greater number of low vitamin D alleles (adjusted OR = 1.33, 95% CI, 1.13-1.58, P < 0.001). Subgroup analyses stratified by sex indicated that the genetic associations were only significant among males with adjusted ORs of 3.77 (95% CI, 1.56-9.10) for the A allele of rs6013897 and 2.04 (95% CI, 1.32-3.17) for GRS.

CONCLUSIONS: Our findings identity CYP24A1-rs6013897 as a potential biomarker for attempted suicide and indicate that a genetic predisposition to lower vitamin D levels may contribute to attempted suicide. It suggests the possibility that vitamin D may have the preventive potential for attempted suicide.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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