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Kong CY, Li ZM, Mao YQ, et al. Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats . Food Funct. 2021;12(20):9773-9783doi: 10.1039/d1fo01836a.
Kong, C. Y., Li, Z. M., Mao, Y. Q., Chen, H. L., Hu, W., Han, B., & Wang, L. S. (2021). Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats . Food & function, 12(20), 9773-9783. https://doi.org/10.1039/d1fo01836a
Kong, Chao-Yue, et al. "Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats ." Food & function vol. 12,20 (2021): 9773-9783. doi: https://doi.org/10.1039/d1fo01836a
Kong CY, Li ZM, Mao YQ, Chen HL, Hu W, Han B, Wang LS. Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats . Food Funct. 2021 Oct 19;12(20):9773-9783. doi: 10.1039/d1fo01836a. PMID: 34494630.
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Food Funct. 2021 Oct 19;12(20):9773-9783. doi: 10.1039/d1fo01836a.

Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats .

Food & function

Chao-Yue Kong, Zhan-Ming Li, Yu-Qin Mao, Hui-Ling Chen, Wei Hu, Bing Han, Li-Shun Wang

Affiliations

  1. Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital, Fudan University, 201100 Shanghai, China. [email protected].
  2. Institute of Fudan-Minhang academic health system, Minhang Hospital, Fudan University, 201100 Shanghai, China.
  3. Department of Cardiology, Minhang Hospital, Fudan University, 201100 Shanghai, China.

PMID: 34494630 DOI: 10.1039/d1fo01836a

Abstract

Dietary intake of probiotic yogurt, which has beneficial effects on intestinal microecology, is associated with a lower incidence of hypertension. Recent studies have shown that the gut microbiota plays a vital role in the development of hypertension. However, the impact of the gut microbiota in the antihypertensive effect of probiotic yogurt remains unclear. Here, we evaluated the impact of the gut microbiota in the antihypertensive effect of probiotic yogurt in spontaneously hypertensive rats (SHR). SHR were treated with probiotic yogurt (0.2 mL per 100 g body weight) (SHR-Y group) for seven weeks and compared with whole milk-treated (0.2 mL per 100 g body weight) SHR (SHR group) and with normotensive Wistar-Kyoto rats (WKY group). The blood pressure and heart function of the rats in the WKY, SHR, and SHR-Y groups were measured. Fecal microbiota was assessed by 16S ribosomal RNA (16S rRNA) gene sequencing. To investigate whether probiotic yogurt prevents hypertension in spontaneously hypertensive rats through the gut microbiota, we co-housed SHR rats (SHR

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