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Canet F, Iannantuoni F, Marañon AM, et al. Does Empagliflozin Modulate Leukocyte-Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?. Antioxidants (Basel). 2021;10(8)doi: 10.3390/antiox10081228.
Canet, F., Iannantuoni, F., Marañon, A. M., Díaz-Pozo, P., López-Domènech, S., Vezza, T., Navarro, B., Solá, E., Falcón, R., Bañuls, C., Morillas, C., Rocha, M., & Víctor, V. M. (2021). Does Empagliflozin Modulate Leukocyte-Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?. Antioxidants (Basel, Switzerland), 10(8), . https://doi.org/10.3390/antiox10081228
Canet, Francisco, et al. "Does Empagliflozin Modulate Leukocyte-Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?." Antioxidants (Basel, Switzerland) vol. 10,8 (2021). doi: https://doi.org/10.3390/antiox10081228
Canet F, Iannantuoni F, Marañon AM, Díaz-Pozo P, López-Domènech S, Vezza T, Navarro B, Solá E, Falcón R, Bañuls C, Morillas C, Rocha M, Víctor VM. Does Empagliflozin Modulate Leukocyte-Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?. Antioxidants (Basel). 2021 Jul 30;10(8). doi: 10.3390/antiox10081228. PMID: 34439476; PMCID: PMC8389001.
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Antioxidants (Basel). 2021 Jul 30;10(8). doi: 10.3390/antiox10081228.

Does Empagliflozin Modulate Leukocyte-Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?.

Antioxidants (Basel, Switzerland)

Francisco Canet, Francesca Iannantuoni, Aránzazu Martínez de Marañon, Pedro Díaz-Pozo, Sandra López-Domènech, Teresa Vezza, Blanca Navarro, Eva Solá, Rosa Falcón, Celia Bañuls, Carlos Morillas, Milagros Rocha, Víctor M Víctor

Affiliations

  1. Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  2. Department of Physiology, University of Valencia, 46010 Valencia, Spain.
  3. CIBERehd-Department of Pharmacology, University of Valencia, 46010 Valencia, Spain.

PMID: 34439476 PMCID: PMC8389001 DOI: 10.3390/antiox10081228

Abstract

Sodium-glucose co-transporter 2 inhibitors (iSGLT2) have been linked to cardiovascular risk reduction in patients with type 2 diabetes (T2D). However, their underlying molecular mechanisms remain unclear. This study aimed to evaluate the effects of empagliflozin, a novel potent and selective iSGLT-2, on anthropometric and endocrine parameters, leukocyte-endothelium interactions, adhesion molecules, ROS production, and NFkB-p65 transcription factor expression. According to standard clinical protocols, sixteen T2D patients receiving 10 mg/day of empagliflozin were followed-up for 24 weeks. Anthropometric and analytical measurements were performed at baseline, 12 weeks, and 24 weeks. Interactions between polymorphonuclear leukocytes and human umbilical vein endothelial cells (HUVECs), serum levels of adhesion molecules (P-Selectin, VCAM-1 and ICAM-1) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), mitochondrial ROS levels, antioxidant enzymes (

Keywords: cardiovascular risk; empagliflozin; inflammation; oxidative stress; type 2 diabetes

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