Display options
Cite
Garcia-Senosiain A, Kana IH, Singh S, et al. Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria. Commun Biol. 2021;4(1):984doi: 10.1038/s42003-021-02511-5.
Garcia-Senosiain, A., Kana, I. H., Singh, S., Das, M. K., Dziegiel, M. H., Hertegonne, S., Adu, B., & Theisen, M. (2021). Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria. Communications biology, 4(1), 984. https://doi.org/10.1038/s42003-021-02511-5
Garcia-Senosiain, Asier, et al. "Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria." Communications biology vol. 4,1 (2021): 984. doi: https://doi.org/10.1038/s42003-021-02511-5
Garcia-Senosiain A, Kana IH, Singh S, Das MK, Dziegiel MH, Hertegonne S, Adu B, Theisen M. Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria. Commun Biol. 2021 Aug 19;4(1):984. doi: 10.1038/s42003-021-02511-5. PMID: 34413459; PMCID: PMC8376957.
Copy Download .nbib Format: NLM
Share it on

Commun Biol. 2021 Aug 19;4(1):984. doi: 10.1038/s42003-021-02511-5.

Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria.

Communications biology

Asier Garcia-Senosiain, Ikhlaq Hussain Kana, Subhash Singh, Manoj Kumar Das, Morten Hanefeld Dziegiel, Sanne Hertegonne, Bright Adu, Michael Theisen

Affiliations

  1. Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
  2. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  3. Indian Institute of Integrative Medicine, Jammu, India. [email protected].
  4. Consytel Life Sciences Pvt. Ltd., Hyderabad, India. [email protected].
  5. National Institute of Malaria Research, Field Unit, Ranchi, Jharkhand, India.
  6. Blood Bank KI 2034, Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  7. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  8. Ghent University, Ghent, Belgium.
  9. Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana. [email protected].
  10. Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. [email protected].
  11. Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. [email protected].

PMID: 34413459 PMCID: PMC8376957 DOI: 10.1038/s42003-021-02511-5

Abstract

Antibody-mediated opsonic phagocytosis (OP) of Plasmodium falciparum blood-stage merozoites has been associated with protection against malaria. However, the precise contribution of different peripheral blood phagocytes in the OP mechanism remains unknown. Here, we developed an in vitro OP assay using peripheral blood leukocytes that allowed us to quantify the contribution of each phagocytic cell type in the OP of merozoites. We found that CD14 

© 2021. The Author(s).

References

  1. Infect Immun. 2020 Mar 23;88(4): - PubMed
  2. Nat Commun. 2021 Mar 19;12(1):1742 - PubMed
  3. Malar J. 2017 May 2;16(1):181 - PubMed
  4. Int J Parasitol. 2017 Sep;47(10-11):585-595 - PubMed
  5. Infect Immun. 1983 Jan;39(1):1-6 - PubMed
  6. Parasitology. 2018 Jun;145(7):839-847 - PubMed
  7. Immunity. 2015 Mar 17;42(3):580-90 - PubMed
  8. J Infect Dis. 2019 Jun 19;220(2):275-284 - PubMed
  9. Parasitology. 2009 Oct;136(12):1445-56 - PubMed
  10. Trends Parasitol. 2004 Dec;20(12):597-603 - PubMed
  11. Infect Immun. 1983 Jul;41(1):219-23 - PubMed
  12. Blood Adv. 2019 Jun 11;3(11):1761-1773 - PubMed
  13. Blood. 2019 Mar 28;133(13):1395-1405 - PubMed
  14. Sci Immunol. 2019 Oct 18;4(40): - PubMed
  15. Malar J. 2014 Oct 20;13:412 - PubMed
  16. Blood. 2009 Apr 16;113(16):3716-25 - PubMed
  17. PLoS One. 2010 Mar 25;5(3):e9871 - PubMed
  18. FEMS Microbiol Rev. 2016 May;40(3):343-72 - PubMed
  19. J Infect Dis. 2017 Feb 15;215(4):623-630 - PubMed
  20. PLoS One. 2013 Sep 09;8(9):e74627 - PubMed
  21. PLoS One. 2012;7(9):e46197 - PubMed
  22. Parasite Immunol. 1988 Jan;10(1):47-58 - PubMed
  23. Annu Rev Immunol. 1983;1:361-92 - PubMed
  24. J Exp Med. 1992 May 1;175(5):1381-90 - PubMed
  25. Front Immunol. 2018 Dec 19;9:3005 - PubMed
  26. BMC Med. 2014 Jul 01;12:108 - PubMed
  27. Open Forum Infect Dis. 2015 Apr 10;2(2):ofv044 - PubMed
  28. J Exp Med. 1990 Dec 1;172(6):1633-41 - PubMed
  29. Trends Parasitol. 2020 Jun;36(6):501-503 - PubMed
  30. Nat Commun. 2019 Feb 5;10(1):610 - PubMed
  31. PLoS One. 2012;7(12):e51692 - PubMed
  32. Infect Immun. 2001 May;69(5):3286-94 - PubMed
  33. J Immunol. 2008 Apr 1;180(7):5083-91 - PubMed
  34. Traffic. 2012 Aug;13(8):1062-71 - PubMed
  35. Nature. 1961 Nov 25;192:733-7 - PubMed
  36. Trends Parasitol. 2001 Nov;17(11):545-51 - PubMed

Publication Types