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Cunha GR, Cao M, Derpinghaus A, et al. Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development. Differentiation. 2021;121:1-12doi: 10.1016/j.diff.2021.08.002.
Cunha, G. R., Cao, M., Derpinghaus, A., Baskin, L. S., Cooke, P., & Walker, W. (2021). Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development. Differentiation; research in biological diversity, 1211-12. https://doi.org/10.1016/j.diff.2021.08.002
Cunha, Gerald R, et al. "Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development." Differentiation; research in biological diversity vol. 121 (2021): 1-12. doi: https://doi.org/10.1016/j.diff.2021.08.002
Cunha GR, Cao M, Derpinghaus A, Baskin LS, Cooke P, Walker W. Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development. Differentiation. 2021 Sep-Oct;121:1-12. doi: 10.1016/j.diff.2021.08.002. Epub 2021 Aug 14. PMID: 34416482.
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Differentiation. 2021 Sep-Oct;121:1-12. doi: 10.1016/j.diff.2021.08.002. Epub 2021 Aug 14.

Cornification and classical versus nonclassical androgen receptor signaling in mouse penile/preputial development.

Differentiation; research in biological diversity

Gerald R Cunha, Mei Cao, Amber Derpinghaus, Laurence S Baskin, Paul Cooke, William Walker

Affiliations

  1. Department of Urology, University of California, 400 Parnassus Avenue, San Francisco, CA, USA, 94143. Electronic address: [email protected].
  2. Department of Urology, University of California, 400 Parnassus Avenue, San Francisco, CA, USA, 94143.
  3. Department of Physiological Sciences, University of Florida, Gainesville, FL, USA, 32610.
  4. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA, 15213, USA.

PMID: 34416482 DOI: 10.1016/j.diff.2021.08.002

Abstract

Mouse penile development is androgen-dependent. During development of male and female external genitalia, an internal ectodermal epithelial structure forms called the preputial lamina. At puberty the male preputial lamina canalizes to create the preputial space, effectively splitting into two layers: (a) the epithelial lining of the prepuce and (b) the surface epithelium of the penis. The female preputial lamina does not canalize, and instead remodels into the inverted U-shaped clitoral lamina of the adult female mouse. Androgen-dependent penile development was studied in transgenic mice with pathway-selective AR mutant transgenes through which AR signaling was activated either via the classical (AR-C) or the nonclassical pathway (AR-NC). Penile development and canalization of the preputial lamina was observed in AR-C and wild-type male mice naturally having both AR-C and AR-NC pathways. Conversely, clitoral development occurred in AR null (lacking both AR-C and AR-NC pathways) and AR-NC mice. The process of canalization of the preputial lamina seen in wild-type, AR-C and AR-C/AR-NC male mice involved cornification of the preputial lamina which involved up-regulation of keratin 10 and loricrin. Such up-regulation of these epidermal proteins was absent in the developing and adult clitoral lamina seen in wild-type female mice and AR-NC and AR null male (XY) mice. Thus, signaling through AR-C is sufficient to initiate and promote penile development and canalization of the preputial lamina, a process involving epithelial cornification.

Copyright © 2021 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

Keywords: Androgen receptor; External prepuce; Mouse; Penis; Preputial lamina; Testosterone

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