Biotechnol J. 2021 Sep 09;e2100183. doi: 10.1002/biot.202100183. Epub 2021 Sep 09.

Hydroxypropyl methylcellulose/graphene oxide composite as drug carrier system for5-Fluorouracil.

Biotechnology journal

Mohamed S Hasanin, Mohamed El-Sakhawy, Hanaa Y Ahmed, Samir Kamel

PMID: 34499787 DOI: 10.1002/biot.202100183

Abstract

AIM: This study aims to prepare green nanocomposite (HPMC/5-FL@GO) from the most biocompatible materials, hydroxypropyl methylcellulose (HPMC) and graphene oxide (GO), to enhance the drug activity of immobilized 5- Fluorouracil (5-FU) with decreasing the side effect of long-run treatment protocols with highly efficient drug-drug activity.

METHOD AND RESULTS: Different samples were characterized by ATR-FTIR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) coupled with energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), Thermogravimetric analysis (TGA), and dynamic light scattering (DLS) along with cytotoxicity and anticancer study. A homogenous and compatible nanocomposite structure with a homogenous drug distribution was confirmed. The results suggested that the prepared nanocomposite has a low cytotoxicity effect against normal Vero cell lines compared with 5-FU. The antitumor activities of the same nanocomposite (20.4 and 74.3 μg/ml on A549 and HepG-2) were lower than that of 5-FU (54.1and 103 μg/ml on A549 and HepG-2).

CONCLUSION AND IMPLICATIONS: According to the attained results, the HPMC/5-FL@GO can be expected to be widely applied in a biomedical application such as cancer therapy with the unique biocompatible to human cells. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Keywords: 5-fluorouracil; anticancer; cellulose; cytotoxicity; graphene oxide

Publication Types

• Journal Article