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Nishida S, Kawauchi S, Toyooka T, et al. Local Application of Magnesium Sulfate Solution Suppressed Cortical Spreading Ischemia and Reduced Brain Damage in a Rat Subarachnoid Hemorrhage-Mimicking Model. World Neurosurg. 2021;155:e704-e715doi: 10.1016/j.wneu.2021.08.130.
Nishida, S., Kawauchi, S., Toyooka, T., Kumagai, K., Takeuchi, S., Sato, S., Kondo, A., Wada, K., & Mori, K. (2021). Local Application of Magnesium Sulfate Solution Suppressed Cortical Spreading Ischemia and Reduced Brain Damage in a Rat Subarachnoid Hemorrhage-Mimicking Model. World neurosurgery, 155e704-e715. https://doi.org/10.1016/j.wneu.2021.08.130
Nishida, Sho, et al. "Local Application of Magnesium Sulfate Solution Suppressed Cortical Spreading Ischemia and Reduced Brain Damage in a Rat Subarachnoid Hemorrhage-Mimicking Model." World neurosurgery vol. 155 (2021): e704-e715. doi: https://doi.org/10.1016/j.wneu.2021.08.130
Nishida S, Kawauchi S, Toyooka T, Kumagai K, Takeuchi S, Sato S, Kondo A, Wada K, Mori K. Local Application of Magnesium Sulfate Solution Suppressed Cortical Spreading Ischemia and Reduced Brain Damage in a Rat Subarachnoid Hemorrhage-Mimicking Model. World Neurosurg. 2021 Nov;155:e704-e715. doi: 10.1016/j.wneu.2021.08.130. Epub 2021 Sep 06. PMID: 34500101.
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World Neurosurg. 2021 Nov;155:e704-e715. doi: 10.1016/j.wneu.2021.08.130. Epub 2021 Sep 06.

Local Application of Magnesium Sulfate Solution Suppressed Cortical Spreading Ischemia and Reduced Brain Damage in a Rat Subarachnoid Hemorrhage-Mimicking Model.

World neurosurgery

Sho Nishida, Satoko Kawauchi, Terushige Toyooka, Kosuke Kumagai, Satoru Takeuchi, Shunichi Sato, Akihide Kondo, Kojiro Wada, Kentaro Mori

Affiliations

  1. Department of Neurosurgery, Social Medical Corporation Shijinkai Ken-o-Tokorozawa Hospital, Tokorozawa, Saitama, Japan; Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: [email protected].
  2. Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan.
  3. Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
  4. Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
  5. Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Neurosurgery, Tokyo General Hospital, Tokyo, Japan.

PMID: 34500101 DOI: 10.1016/j.wneu.2021.08.130

Abstract

OBJECTIVE: Cortical spreading depolarization (CSD), cortical spreading ischemia (CSI), and early brain injury are involved in the occurrence of delayed brain ischemia after subarachnoid hemorrhage (SAH). We tested whether local application of magnesium (Mg) sulfate solution suppressed CSD and CSI, and decreased brain damage in a rat SAH-mimicking model.

METHODS: Nitric oxide synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME) and high concentration potassium solution were topically applied to simulate the environment after SAH. We irrigated the parietal cortex with artificial cerebrospinal fluid (ACSF), containing L-NAME (1 mM), K

RESULTS: Mg solution significantly shortened the total depolarization time, and reduced CSI, histological brain damage, and brain edema compared with those of the control group (P < 0.05). Body weight loss was significantly suppressed in the Mg group (P < 0.05), but neurological score did not improve.

CONCLUSIONS: Local application of Mg suppressed CSI and reduced brain damage in a rat SAH-mimicking model. Mg irrigation therapy may be beneficial to suppress brain damage due to CSI after SAH.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Cortical spreading depolarization; Delayed brain injury; Early brain injury; Magnesium; Subarachnoid hemorrhage

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