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Li X, Zhu Q, Vanduffel W. Myelin densities in retinotopically defined dorsal visual areas of the macaque. Brain Struct Funct. 2021;226(9):2869-2880doi: 10.1007/s00429-021-02363-z.
Li, X., Zhu, Q., & Vanduffel, W. (2021). Myelin densities in retinotopically defined dorsal visual areas of the macaque. Brain structure & function, 226(9), 2869-2880. https://doi.org/10.1007/s00429-021-02363-z
Li, Xiaolian, et al. "Myelin densities in retinotopically defined dorsal visual areas of the macaque." Brain structure & function vol. 226,9 (2021): 2869-2880. doi: https://doi.org/10.1007/s00429-021-02363-z
Li X, Zhu Q, Vanduffel W. Myelin densities in retinotopically defined dorsal visual areas of the macaque. Brain Struct Funct. 2021 Dec;226(9):2869-2880. doi: 10.1007/s00429-021-02363-z. Epub 2021 Aug 21. PMID: 34417886; PMCID: PMC8541961.
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Brain Struct Funct. 2021 Dec;226(9):2869-2880. doi: 10.1007/s00429-021-02363-z. Epub 2021 Aug 21.

Myelin densities in retinotopically defined dorsal visual areas of the macaque.

Brain structure & function

Xiaolian Li, Qi Zhu, Wim Vanduffel

Affiliations

  1. Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000, Leuven, Belgium.
  2. Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000, Leuven, Belgium. [email protected].
  3. Cognitive Neuroimaging Unit, INSERM, CEA, Université Paris-Saclay, NeuroSpin Center, 91191, Gif/Yvette, France. [email protected].
  4. Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000, Leuven, Belgium. [email protected].
  5. Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium. [email protected].
  6. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA. [email protected].
  7. Department of Radiology, Harvard Medical School, Boston, MA, 02144, USA. [email protected].

PMID: 34417886 PMCID: PMC8541961 DOI: 10.1007/s00429-021-02363-z

Abstract

The visuotopic organization of dorsal visual cortex rostral to area V2 in primates has been a longstanding source of controversy. Using sub-millimeter phase-encoded retinotopic fMRI mapping, we recently provided evidence for a surprisingly similar visuotopic organization in dorsal visual cortex of macaques compared to previously published maps in New world monkeys (Zhu and Vanduffel, Proc Natl Acad Sci USA 116:2306-2311, 2019). Although individual quadrant representations could be robustly delineated in that study, their grouping into hemifield representations remains a major challenge. Here, we combined in-vivo high-resolution myelin density mapping based on MR imaging (400 µm isotropic resolution) with fine-grained retinotopic fMRI to quantitatively compare myelin densities across retinotopically defined visual areas in macaques. Complementing previously documented differences in populational receptive-field (pRF) size and visual field signs, myelin densities of both quadrants of the dorsolateral posterior area (DLP) and area V3A are significantly different compared to dorsal and ventral area V3. Moreover, no differences in myelin density were observed between the two matching quadrants belonging to areas DLP, V3A, V1, V2 and V4, respectively. This was not the case, however, for the dorsal and ventral quadrants of area V3, which showed significant differences in MR-defined myelin densities, corroborating evidence of previous myelin staining studies. Interestingly, the pRF sizes and visual field signs of both quadrant representations in V3 are not different. Although myelin density correlates with curvature and anticorrelates with cortical thickness when measured across the entire cortex, exactly as in humans, the myelin density results in the visual areas cannot be explained by variability in cortical thickness and curvature between these areas. The present myelin density results largely support our previous model to group the two quadrants of DLP and V3A, rather than grouping DLP- with V3v into a single area VLP, or V3d with V3A+ into DM.

© 2021. The Author(s).

Keywords: MRI; Myelination; Non-human primate; Visual cortex

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