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Chen L, Al-Bayatee S, Khurshid Z, et al. Hydroxyapatite in Oral Care Products-A Review. Materials (Basel). 2021;14(17)doi: 10.3390/ma14174865.
Chen, L., Al-Bayatee, S., Khurshid, Z., Shavandi, A., Brunton, P., & Ratnayake, J. (2021). Hydroxyapatite in Oral Care Products-A Review. Materials (Basel, Switzerland), 14(17), . https://doi.org/10.3390/ma14174865
Chen, Lijie, et al. "Hydroxyapatite in Oral Care Products-A Review." Materials (Basel, Switzerland) vol. 14,17 (2021). doi: https://doi.org/10.3390/ma14174865
Chen L, Al-Bayatee S, Khurshid Z, Shavandi A, Brunton P, Ratnayake J. Hydroxyapatite in Oral Care Products-A Review. Materials (Basel). 2021 Aug 27;14(17). doi: 10.3390/ma14174865. PMID: 34500955; PMCID: PMC8432723.
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Materials (Basel). 2021 Aug 27;14(17). doi: 10.3390/ma14174865.

Hydroxyapatite in Oral Care Products-A Review.

Materials (Basel, Switzerland)

Lijie Chen, Suma Al-Bayatee, Zohaib Khurshid, Amin Shavandi, Paul Brunton, Jithendra Ratnayake

Affiliations

  1. Department of Oral Science, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.
  2. Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
  3. BioMatter Unit-École Polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Avenue F.D. Roosevelt, 50-CP 165/61, 1050 Brussels, Belgium.

PMID: 34500955 PMCID: PMC8432723 DOI: 10.3390/ma14174865

Abstract

Calcium phosphate compounds form the inorganic phases of our mineralised tissues such as bone and teeth, playing an important role in hard tissue engineering and regenerative medicine. In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such as tooth remineralisation, reduction of tooth sensitivity, oral biofilm control, and tooth whitening. Clinical data on these products is limited with varied results; additionally, the effectiveness of these apatite compounds versus fluoride, which has conventionally been used in toothpaste, has not been established. Therefore, this review critically evaluates current research on HA oral care, and discusses the role and mechanism of HA in remineralisation of both enamel and dentine and for suppressing dentine sensitivity. Furthermore, we position HA's role in biofilm management and highlight the role of HA in dental applications by summarising the recent achievement and providing an overview of commercialised HA dental products. The review also indicates the existing limitations and provides direction for future research and commercialisation of apatite-based oral care products.

Keywords: biofilm; dentine hypersensitivity; hydroxyapatite; hydroxyapatite toothpaste; remineralisation; teeth whitening

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