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Xu DM, Yu WJ, Xie L, et al. The diagnostic profile of rare acute myelomegakaryoblastic leukemia. Leuk Lymphoma. 2021;62(13):3204-3211doi: 10.1080/10428194.2021.1955878.
Xu, D. M., Yu, W. J., Xie, L., Zhang, Z. W., Qiu, J. F., Xu, C. W., He, C. L., Xu, X. R., Xu, J. S., Li, Q., & Yin, J. (2021). The diagnostic profile of rare acute myelomegakaryoblastic leukemia. Leukemia & lymphoma, 62(13), 3204-3211. https://doi.org/10.1080/10428194.2021.1955878
Xu, Da-Ming, et al. "The diagnostic profile of rare acute myelomegakaryoblastic leukemia." Leukemia & lymphoma vol. 62,13 (2021): 3204-3211. doi: https://doi.org/10.1080/10428194.2021.1955878
Xu DM, Yu WJ, Xie L, Zhang ZW, Qiu JF, Xu CW, He CL, Xu XR, Xu JS, Li Q, Yin J. The diagnostic profile of rare acute myelomegakaryoblastic leukemia. Leuk Lymphoma. 2021 Dec;62(13):3204-3211. doi: 10.1080/10428194.2021.1955878. Epub 2021 Sep 03. PMID: 34477034.
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Leuk Lymphoma. 2021 Dec;62(13):3204-3211. doi: 10.1080/10428194.2021.1955878. Epub 2021 Sep 03.

The diagnostic profile of rare acute myelomegakaryoblastic leukemia.

Leukemia & lymphoma

Da-Ming Xu, Wen-Jun Yu, Long Xie, Ze-Wen Zhang, Jin-Feng Qiu, Cheng-Wei Xu, Chun-Ling He, Xian-Ru Xu, Jie-Song Xu, Qian Li, Jun Yin

Affiliations

  1. Division of Urological Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  2. Division of Hematology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  3. Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  4. Division of Respirology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  5. Department of Blood Purification, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  6. Department of Pathology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  7. Division of Inventional Ultrasonic Therapeutics, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
  8. Department of Electroencephalogram, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

PMID: 34477034 DOI: 10.1080/10428194.2021.1955878

Abstract

Acute myelomagakaryocytic leukemia is a diagnostic and therapeutic challenge owing to its heterogeneity and overlapping features with other types of acute leukemia. In order to build a diagnostic profile, we analyzed the biological, clinical and hematologic characteristics of acute myelomagakaryocytic leukemia. We found that, in three patients diagnosed with acute myelomagakaryocytic leukemia, there were two types of leukemia cells. One type was myeloblastic with positive peroxidase (POX) stainig and the expression of antigens CD13 and CD33. The other type was megakaryoblastic with negative POX staining and the expression of antigens CD36, CD41, CD42a and CD61. Three patients displayed the same cytogenetic abnormality, a (9: 22) translocation. Among the three patients with RT-PCR, two patients displayed BCR-ABL fusion gene amplification and one patient showed a previously undescribed OTT-MAL fusion gene amplification.

Keywords: Acute myelomagakaryocytic leukemia; diagnosis; genetic mutation

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