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Boltsis I, Grosveld F, Giraud G, et al. Chromatin Conformation in Development and Disease. Front Cell Dev Biol. 2021;9:723859doi: 10.3389/fcell.2021.723859.
Boltsis, I., Grosveld, F., Giraud, G., & Kolovos, P. (2021). Chromatin Conformation in Development and Disease. Frontiers in cell and developmental biology, 9723859. https://doi.org/10.3389/fcell.2021.723859
Boltsis, Ilias, et al. "Chromatin Conformation in Development and Disease." Frontiers in cell and developmental biology vol. 9 (2021): 723859. doi: https://doi.org/10.3389/fcell.2021.723859
Boltsis I, Grosveld F, Giraud G, Kolovos P. Chromatin Conformation in Development and Disease. Front Cell Dev Biol. 2021 Aug 04;9:723859. doi: 10.3389/fcell.2021.723859. eCollection 2021. PMID: 34422840; PMCID: PMC8371409.
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Front Cell Dev Biol. 2021 Aug 04;9:723859. doi: 10.3389/fcell.2021.723859. eCollection 2021.

Chromatin Conformation in Development and Disease.

Frontiers in cell and developmental biology

Ilias Boltsis, Frank Grosveld, Guillaume Giraud, Petros Kolovos

Affiliations

  1. Department of Cell Biology, Erasmus Medical Centre, Rotterdam, Netherlands.
  2. Cancer Research Center of Lyon - INSERM U1052, Lyon, France.
  3. Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.

PMID: 34422840 PMCID: PMC8371409 DOI: 10.3389/fcell.2021.723859

Abstract

Chromatin domains and loops are important elements of chromatin structure and dynamics, but much remains to be learned about their exact biological role and nature. Topological associated domains and functional loops are key to gene expression and hold the answer to many questions regarding developmental decisions and diseases. Here, we discuss new findings, which have linked chromatin conformation with development, differentiation and diseases and hypothesized on various models while integrating all recent findings on how chromatin architecture affects gene expression during development, evolution and disease.

Copyright © 2021 Boltsis, Grosveld, Giraud and Kolovos.

Keywords: TAD; cancer; chromatin conformation; development; differentiation; disease; gene regulation; regulatory element

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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