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Front Med (Lausanne). 2021 Aug 05;8:655084. doi: 10.3389/fmed.2021.655084. eCollection 2021.

Unsupervised Phonocardiogram Analysis With Distribution Density Based Variational Auto-Encoders.

Frontiers in medicine

Shengchen Li, Ke Tian

Affiliations

  1. Department of Interlligent Science, Xi'an Jiaotong-Liverpool University, Suzhou, China.
  2. College of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, China.

PMID: 34422847 PMCID: PMC8374324 DOI: 10.3389/fmed.2021.655084

Abstract

This paper proposes an unsupervised way for Phonocardiogram (PCG) analysis, which uses a revised auto encoder based on distribution density estimation in the latent space. Auto encoders especially Variational Auto-Encoders (VAEs) and its variant β-VAE are considered as one of the state-of-the-art methodologies for PCG analysis. VAE based models for PCG analysis assume that normal PCG signals can be represented by latent vectors that obey a normal Gaussian Model, which may not be necessary true in PCG analysis. This paper proposes two methods DBVAE and DBAE that are based on estimating the density of latent vectors in latent space to improve the performance of VAE based PCG analysis systems. Examining the system performance with PCG data from the a single domain and multiple domains, the proposed systems outperform the VAE based methods. The representation of normal PCG signals in the latent space is also investigated by calculating the kurtosis and skewness where DBAE introduces normal PCG representation following Gaussian-like models but DBVAE does not introduce normal PCG representation following Gaussian-like models.

Copyright © 2021 Li and Tian.

Keywords: abnormality detection; auto-encoder; data density; phonocardiogram analysis; unsupervised learning

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Physiol Meas. 2016 Dec;37(12):2181-2213 - PubMed
  2. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:74-77 - PubMed

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