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Ingegnoli F, Coletto LA, Scotti I, et al. The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?. Front Med (Lausanne). 2021;8:705382doi: 10.3389/fmed.2021.705382.
Ingegnoli, F., Coletto, L. A., Scotti, I., Compagnoni, R., Randelli, P. S., & Caporali, R. (2021). The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?. Frontiers in medicine, 8705382. https://doi.org/10.3389/fmed.2021.705382
Ingegnoli, Francesca, et al. "The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?." Frontiers in medicine vol. 8 (2021): 705382. doi: https://doi.org/10.3389/fmed.2021.705382
Ingegnoli F, Coletto LA, Scotti I, Compagnoni R, Randelli PS, Caporali R. The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?. Front Med (Lausanne). 2021 Aug 06;8:705382. doi: 10.3389/fmed.2021.705382. eCollection 2021. PMID: 34422862; PMCID: PMC8377390.
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Front Med (Lausanne). 2021 Aug 06;8:705382. doi: 10.3389/fmed.2021.705382. eCollection 2021.

The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?.

Frontiers in medicine

Francesca Ingegnoli, Lavinia Agra Coletto, Isabella Scotti, Riccardo Compagnoni, Pietro Simone Randelli, Roberto Caporali

Affiliations

  1. Division of Clinical Rheumatology, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano, Italy.
  2. Department of Clinical Sciences & Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Research Center for Environmental Health, Università degli Studi di Milano, Milano, Italy.
  3. 1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano, Italy.
  4. Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milano, Italy.
  5. Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.

PMID: 34422862 PMCID: PMC8377390 DOI: 10.3389/fmed.2021.705382

Abstract

In the majority of joint diseases, changes in the organization of the synovial architecture appear early. Synovial tissue analysis might provide useful information for the diagnosis, especially in atypical and rare joint disorders, and might have a value in case of undifferentiated inflammatory arthritis, by improving disease classification. After patient selection, it is crucial to address the dialogue between the clinician and the pathologist for adequately handling the sample, allowing identifying histological patterns depending on the clinical suspicion. Moreover, synovial tissue analysis gives insight into disease progression helping patient stratification, by working as an actionable and mechanistic biomarker. Finally, it contributes to an understanding of joint disease pathogenesis holding promise for identifying new synovial biomarkers and developing new therapeutic strategies. All of the indications mentioned above are not so far from being investigated in everyday clinical practice in tertiary referral hospitals, thanks to the great feasibility and safety of old and more recent techniques such as ultrasound-guided needle biopsy and needle arthroscopy. Thus, even in rheumatology clinical practice, pathobiology might be a key component in the management and treatment decision-making process. This review aims to examine some essential and crucial points regarding why, when, where, and how to perform a synovial biopsy in clinical practice and research settings and what information you might expect after a proper patient selection.

Copyright © 2021 Ingegnoli, Coletto, Scotti, Compagnoni, Randelli and Caporali.

Keywords: inflammatory arthritis; rheumatoid arthritis; synovial analysis; synovial biopsy; synovial membrane

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Best Pract Res Clin Rheumatol. 2013 Apr;27(2):195-207 - PubMed
  2. J Clin Microbiol. 2003 Apr;41(4):1710-1 - PubMed
  3. Arthritis Res Ther. 2018 Dec 3;20(1):265 - PubMed
  4. J Clin Pathol. 1983 Aug;36(8):860-6 - PubMed
  5. Clin Rheumatol. 2013 Feb;32(2):225-32 - PubMed
  6. Arthroscopy. 2005 Oct;21(10):1209-18 - PubMed
  7. Nat Rev Dis Primers. 2018 Apr 05;4:18016 - PubMed
  8. Rheumatology (Oxford). 2021 Feb 1;60(2):667-674 - PubMed
  9. Baillieres Best Pract Res Clin Rheumatol. 2000 Sep;14(3):461-76 - PubMed
  10. Front Med (Lausanne). 2019 Jun 20;6:138 - PubMed
  11. Autoimmun Rev. 2021 Mar;20(3):102758 - PubMed
  12. Ann Rheum Dis. 2019 Dec;78(12):1642-1652 - PubMed
  13. Best Pract Res Clin Rheumatol. 2012 Aug;26(4):459-75 - PubMed
  14. Ann Rheum Dis. 2019 Jun;78(6):761-772 - PubMed
  15. Eur Radiol. 2001;11(12):2549-60 - PubMed
  16. Lancet. 2021 Jan 23;397(10271):305-317 - PubMed
  17. J Arthroplasty. 2004 Aug;19(5):582-6 - PubMed
  18. Curr Rheumatol Rep. 2015 Jun;17(6):511 - PubMed
  19. Arthritis Rheum. 1989 Apr;32(4):361-9 - PubMed
  20. Best Pract Res Clin Rheumatol. 2009 Apr;23(2):221-32 - PubMed
  21. Am J Med. 2016 May;129(5):536.e1-6 - PubMed
  22. J Rheumatol. 1999 Apr;26(4):777-84 - PubMed
  23. Trop Parasitol. 2014 Jul;4(2):80-9 - PubMed
  24. Ann Rheum Dis. 2004 Feb;63(2):130 - PubMed
  25. Arthritis Rheum. 1996 Jan;39(1):115-24 - PubMed
  26. J R Coll Surg Edinb. 1990 Aug;35(4):259-62 - PubMed
  27. Arthritis Res Ther. 2005;7(3):R569-80 - PubMed
  28. Arthritis Rheum. 2001 Oct;44(10):2255-62 - PubMed
  29. Front Med (Lausanne). 2021 Apr 09;8:656667 - PubMed
  30. Arthritis Rheum. 2002 Aug;46(8):2034-8 - PubMed
  31. Front Immunol. 2020 May 05;11:845 - PubMed
  32. Arthritis Rheum. 2001 Oct;44(10):2263-74 - PubMed
  33. J Immunol. 2005 Mar 1;174(5):2860-9 - PubMed
  34. Arthritis Rheum. 2004 Sep;50(9):2931-41 - PubMed
  35. Ann Rheum Dis. 2001 Jun;60(6):561-5 - PubMed
  36. Arthroscopy. 2009 Feb;25(2):153-8 - PubMed
  37. Ann Rheum Dis. 1992 May;51(5):690-7 - PubMed
  38. J Rheumatol. 2016 Dec;43(12):2113-2119 - PubMed
  39. Arthritis Rheum. 2013 Jan;65(1):174-85 - PubMed
  40. Arthritis Res Ther. 2014;16(2):R90 - PubMed
  41. Arthritis Res Ther. 2014 Jan 08;16(1):R5 - PubMed
  42. Arthritis Rheum. 1963 Apr;6:172-6 - PubMed
  43. Rheumatology (Oxford). 2018 May 1;57(5):777-783 - PubMed
  44. RMD Open. 2018 Oct 26;4(2):e000799 - PubMed
  45. Ann Rheum Dis. 2000 Dec;59(12):945-53 - PubMed
  46. Front Med (Lausanne). 2019 Jan 29;6:4 - PubMed
  47. J Rheumatol. 2003 Feb;30(2):260-8 - PubMed
  48. Ann Rheum Dis. 1984 Jun;43(3):523-5 - PubMed
  49. Clin Rheumatol. 2018 Aug;37(8):2241-2249 - PubMed
  50. Br J Radiol. 2016;89(1057):20150363 - PubMed
  51. Ann Rheum Dis. 2006 Jan;65(1):93-100 - PubMed
  52. Ann Rheum Dis. 1951 Sep;10(3):277-87 - PubMed
  53. Braz J Med Biol Res. 1999 Dec;32(12):1467-72 - PubMed
  54. Open Rheumatol J. 2011;5:100-6 - PubMed
  55. Ann Rheum Dis. 1984 Dec;43(6):778-82 - PubMed
  56. Ann Rheum Dis. 2010 Jun;69(6):1214-9 - PubMed
  57. Arthritis Res Ther. 2007;9(5):R101 - PubMed
  58. Arthritis Rheum. 2007 Nov;56(11):3869-71 - PubMed
  59. Arthritis Rheum. 1982 Jun;25(6):677-84 - PubMed
  60. Arthritis Rheum. 1999 Apr;42(4):812-7 - PubMed
  61. Adv Microb Physiol. 2009;55:1-79, 317 - PubMed
  62. PLoS One. 2015 Apr 30;10(4):e0122104 - PubMed
  63. Ann Rheum Dis. 2011 May;70(5):792-8 - PubMed
  64. World J Orthop. 2014 Nov 18;5(5):566-73 - PubMed
  65. J Rheumatol. 2005 Sep;32(9):1666-72 - PubMed
  66. Arthritis Res. 2000;2(2):145-53 - PubMed
  67. Rheumatology (Oxford). 1999 Nov;38(11):1074-80 - PubMed
  68. Rheumatology (Oxford). 2010 Dec;49(12):2237-42 - PubMed
  69. Clin Rheumatol. 1999;18(6):434-41 - PubMed
  70. Front Med (Lausanne). 2019 Mar 21;6:46 - PubMed
  71. Ann Rheum Dis. 2005 Jun;64(6):834-8 - PubMed
  72. Eur J Rheumatol. 2017 Sep;4(3):229-230 - PubMed
  73. Front Med (Lausanne). 2019 Mar 19;6:45 - PubMed
  74. Arthritis Rheum. 2010 Sep;62(9):2569-81 - PubMed
  75. Arthritis Res Ther. 2016 Jan 20;18:19 - PubMed
  76. Curr Opin Rheumatol. 2001 Jan;13(1):74-9 - PubMed
  77. Arthritis Rheumatol. 2018 May;70(5):702-710 - PubMed
  78. Nat Rev Dis Primers. 2016 Dec 15;2:16090 - PubMed
  79. Arthritis Rheum. 1998 Apr;41(4):663-9 - PubMed
  80. J Rheumatol. 2019 Oct;46(10):1365-1368 - PubMed
  81. Br J Rheumatol. 1989 Aug;28(4):287-92 - PubMed
  82. Clin Infect Dis. 2015 Aug 15;61(4):554-62 - PubMed
  83. Ann Rheum Dis. 2017 Jul;76(7):1228-1236 - PubMed
  84. Ann Rheum Dis. 1994 Jan;53(1):39-44 - PubMed
  85. Arthritis Rheum. 2006 Dec;54(12):3761-73 - PubMed

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