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Corbett KM, Ford L, Warren DB, et al. Cyclosporin Structure and Permeability: From A to Z and Beyond. J Med Chem. 2021;64(18):13131-13151doi: 10.1021/acs.jmedchem.1c00580.
Corbett, K. M., Ford, L., Warren, D. B., Pouton, C. W., & Chalmers, D. K. (2021). Cyclosporin Structure and Permeability: From A to Z and Beyond. Journal of medicinal chemistry, 64(18), 13131-13151. https://doi.org/10.1021/acs.jmedchem.1c00580
Corbett, Karen M, et al. "Cyclosporin Structure and Permeability: From A to Z and Beyond." Journal of medicinal chemistry vol. 64,18 (2021): 13131-13151. doi: https://doi.org/10.1021/acs.jmedchem.1c00580
Corbett KM, Ford L, Warren DB, Pouton CW, Chalmers DK. Cyclosporin Structure and Permeability: From A to Z and Beyond. J Med Chem. 2021 Sep 23;64(18):13131-13151. doi: 10.1021/acs.jmedchem.1c00580. Epub 2021 Sep 03. PMID: 34478303.
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J Med Chem. 2021 Sep 23;64(18):13131-13151. doi: 10.1021/acs.jmedchem.1c00580. Epub 2021 Sep 03.

Cyclosporin Structure and Permeability: From A to Z and Beyond.

Journal of medicinal chemistry

Karen M Corbett, Leigh Ford, Dallas B Warren, Colin W Pouton, David K Chalmers

Affiliations

  1. Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.

PMID: 34478303 DOI: 10.1021/acs.jmedchem.1c00580

Abstract

Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and potential pharmaceutical applications. Several members of the cyclosporin compound family have remarkably high passive membrane permeabilities that are not well-described by simple structural metrics. Here we review experimental studies of cyclosporin structure and permeability, including cyclosporin-metal complexes. We also discuss models for the conformation-dependent permeability of cyclosporins and similar compounds. Finally, we identify current knowledge gaps in the literature and provide recommendations regarding future avenues of exploration.

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