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Ginsberg C, Hoofnagle AN, Katz R, et al. The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults. J Bone Miner Res. 2021;doi: 10.1002/jbmr.4426.
Ginsberg, C., Hoofnagle, A. N., Katz, R., Hughes-Austin, J., Miller, L. M., Becker, J. O., Kritchevsky, S. B., Shlipak, M. G., Sarnak, M. J., & Ix, J. H. (2021). The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, . https://doi.org/10.1002/jbmr.4426
Ginsberg, Charles, et al. "The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. (2021). doi: https://doi.org/10.1002/jbmr.4426
Ginsberg C, Hoofnagle AN, Katz R, Hughes-Austin J, Miller LM, Becker JO, Kritchevsky SB, Shlipak MG, Sarnak MJ, Ix JH. The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults. J Bone Miner Res. 2021 Aug 23; doi: 10.1002/jbmr.4426. Epub 2021 Aug 23. PMID: 34423858.
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J Bone Miner Res. 2021 Aug 23; doi: 10.1002/jbmr.4426. Epub 2021 Aug 23.

The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Charles Ginsberg, Andrew N Hoofnagle, Ronit Katz, Jan Hughes-Austin, Lindsay M Miller, Jessica O Becker, Stephen B Kritchevsky, Michael G Shlipak, Mark J Sarnak, Joachim H Ix

Affiliations

  1. Division of Nephrology-Hypertension, University of California San Diego, San Diego, CA, USA.
  2. Departments of Laboratory Medicine and Medicine and the Kidney Research Institute, University of Washington, Seattle, WA, USA.
  3. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
  4. Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
  5. Department of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  6. Kidney Health Research Collaborative, Veterans Affairs Medical Center, San Francisco, CA, USA.
  7. University of California San Francisco, San Francisco, CA, USA.
  8. Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA.

PMID: 34423858 DOI: 10.1002/jbmr.4426

Abstract

Recent studies have suggested that 25-hydroxyvitamin D (25(OH)D) may be a poor biomarker of bone health, in part because measured levels incorporate both protein-bound and free vitamin D. The ratio of its catabolic product (24,25-dihydroxyvitamin D [24,25(OH)

© 2021 American Society for Bone and Mineral Research (ASBMR).

Keywords: DXA; FRACTURE PREVENTION; OSTEOPOROSIS; PTH/VITAMIN D/FGF23

References

  1. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004;116(9):634-639. - PubMed
  2. Priemel M, von Domarus C, Klatte TO, et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2010;25(2):305-312. - PubMed
  3. Ginsberg C, Katz R, de Boer IH, et al. The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: the Cardiovascular Health Study. Bone. 2018;107:124-130. - PubMed
  4. Burt LA, Billington EO, Rose MS, Raymond DA, Hanley DA, Boyd SK. Effect of high-dose vitamin D supplementation on volumetric bone density and bone strength: a randomized clinical trial. JAMA. 2019;322(8):736-745. - PubMed
  5. LeBoff MS, Chou SH, Murata EM, et al. Effects of supplemental vitamin D on bone health outcomes in women and men in the VITamin D and OmegA-3 TriaL (VITAL). J Bone Miner Res. 2020;35(5):883-893. - PubMed
  6. Souberbielle JC, Cavalier E, Delanaye P, et al. Serum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations. Clin Chim Acta. 2015;451(Pt B):149-153. - PubMed
  7. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930. - PubMed
  8. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 2008;88(2):582S-586S. - PubMed
  9. Tryfonidou MA, Oosterlaken-Dijksterhuis MA, Mol JA, van den Ingh TS, van den Brom WE, Hazewinkel HA. 24-hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs. Am J Physiol Endocrinol Metab. 2003;284(3):E505-E513. - PubMed
  10. Cavalier E, Huyghebaert L, Rousselle O, et al. Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects. Clin Chem Lab Med. 2020;58(2):197-201. - PubMed
  11. Powe CE, Ricciardi C, Berg AH, et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011;26:1609-1616. - PubMed
  12. Ginsberg C, Hoofnagle AN, Katz R, et al. The vitamin D metabolite ratio is independent of vitamin D binding protein concentration. Clin Chem. 2021;67(2):385-393. - PubMed
  13. Selamet U, Katz R, Ginsberg C, et al. Serum calcitriol concentrations and kidney function decline, heart failure, and mortality in elderly community-living adultspersons: the Health, Aging and Body Composition Study. Am J Kidney Dis. 2018;72(3):419-428. - PubMed
  14. Fredman L, Cauley JA, Satterfield S, et al. Caregiving, mortality, and mobility decline: the Health, Aging, and Body Composition (Health ABC) Study. Arch Intern Med. 2008;168(19):2154-2162. - PubMed
  15. Lloyd J, Alley D, Hochberg M, et al. Changes in bone mineral density over time by body mass index in the Health ABC Study. Osteoporos Int. 2016;27:2109-2116. - PubMed
  16. Henderson CM, Lutsey PL, Misialek JR. Measurement by a novel LC-MS/MS methodology reveals similar serum concentrations of vitamin D-binding protein in blacks and whites. Clin Chem. 2016;62(1):179-187. - PubMed
  17. Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-29. - PubMed
  18. van Ballegooijen AJ, Robinson-Cohen C, Katz R, et al. Vitamin D metabolites and bone mineral density: the multi-ethnic study of atherosclerosis. Bone. 2015;78:186-193. - PubMed
  19. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr. 1995;61:1140-1145. - PubMed
  20. Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009;94:67-73. - PubMed
  21. Regard JB, Zhong Z, Williams BO, Yang Y. Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harb Perspect Biol. 2012;4(12):a007997. - PubMed
  22. Parfitt AM, Mathews CH, Brommage R, Jarnagin K, DeLuca HF. Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat. J Clin Invest. 1984;73(2):576-586. - PubMed
  23. Curtis KM, Aenlle KK, Roos BA, Howard GA. 24R,25-dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells. Mol Endocrinol. 2014;28(5):644-658. - PubMed
  24. Ornoy A, Goodwin D, Noff D, Edelstein S. 24, 25-dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation. Nature. 1978;276(5687):517-519. - PubMed
  25. Bosworth CR, Levin G, Robinson-Cohen C, et al. The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease. Kidney Int. 2012;82(6):693-700. - PubMed
  26. Berg AH, Bhan I, Powe C, et al. Acute homeostatic changes following vitamin D2 supplementation. J Endocr Soc. 2017;1:1135-1149. - PubMed
  27. Ginsberg C, Zelnick LR, Block GA, et al. Differential effects of phosphate binders on vitamin D metabolism in chronic kidney disease. Nephrol Dial Transplant. 2020;35(4):616-623. - PubMed

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