Display options
Cite
Klug J, Christensen S, Imai DM, et al. The geropathology of organ-specific aging. J Transl Sci. 2021;7(1)doi: 10.15761/jts.1000458.
Klug, J., Christensen, S., Imai, D. M., Snider, T. A., & Ladiges, W. (2021). The geropathology of organ-specific aging. Journal of translational science, 7(1), . https://doi.org/10.15761/jts.1000458
Klug, Jenna, et al. "The geropathology of organ-specific aging." Journal of translational science vol. 7,1 (2021). doi: https://doi.org/10.15761/jts.1000458
Klug J, Christensen S, Imai DM, Snider TA, Ladiges W. The geropathology of organ-specific aging. J Transl Sci. 2021 Feb;7(1). doi: 10.15761/jts.1000458. Epub 2021 Jun 16. PMID: 34504718; PMCID: PMC8425292.
Copy Download .nbib Format: NLM
Share it on

J Transl Sci. 2021 Feb;7(1). doi: 10.15761/jts.1000458. Epub 2021 Jun 16.

The geropathology of organ-specific aging.

Journal of translational science

Jenna Klug, Sara Christensen, Denise M Imai, Timothy A Snider, Warren Ladiges

Affiliations

  1. Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
  2. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA.
  3. Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA.

PMID: 34504718 PMCID: PMC8425292 DOI: 10.15761/jts.1000458

Abstract

Aging is a complex multidimensional process of progressive decline affecting multiple organ systems by a number of processes that are still not well understood. While many studies have focused on the approach of studying aging across multiple organs, assessment of the contribution of individual organs to overall aging processes is under appreciated. The ability to study and compare organs in the context of organismal aging has been documented recently using a geropathology grading platform in laboratory mice. This concept consists of identifying and grading age-related histologic lesions within organs to generate a quantitative lesion score for each organ, which is representative of the presence and degree of organ-related pathology, and can be compared to scores from other organs examined. This geropathology approach provides a powerful tool to elucidate the basic mechanisms of aging in multiple organs, as well as the response of organs to therapeutic interventions. Furthermore, ongoing work with the concept has expanded and adapted the geropathology grading system to other preclinical animal model species that are commonly used to understand disease associated phenotypes in aging humans, ultimately adding to the utility of the concept.

Keywords: age-related lesions; anti-aging drug responsive organs; geropathology; organ-specific aging

References

  1. Aging Pathobiol Ther. 2020;2(1):16-19 - PubMed
  2. Geroscience. 2019 Aug;41(4):455-465 - PubMed
  3. EBioMedicine. 2018 Oct;36:18-28 - PubMed
  4. J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762 - PubMed
  5. Pathobiol Aging Age Relat Dis. 2016 Mar 23;6:31478 - PubMed
  6. Pathobiol Aging Age Relat Dis. 2017 Mar 21;7(1):1304005 - PubMed

Publication Types

Grant support