Display options
Cite
Descamps A, Lenzi N, Galtier F, et al. In-hospital and midterm out-hospital complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study. Eur Respir J. 2021;doi: 10.1183/13993003.00651-2021.
Descamps, A., Lenzi, N., Galtier, F., Lainé, F., Lesieur, Z., Vanhems, P., Amour, S., L'Honneur, A. S., Fidouh, N., Foulongne, V., Lagathu, G., Duval, X., Merle, C., Lina, B., Carrat, F., Launay, O., Loubet, P. (2021). In-hospital and midterm out-hospital complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study. The European respiratory journal, . https://doi.org/10.1183/13993003.00651-2021
Descamps, Alexandre, et al. "In-hospital and midterm out-hospital complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study." The European respiratory journal vol. (2021). doi: https://doi.org/10.1183/13993003.00651-2021
Descamps A, Lenzi N, Galtier F, Lainé F, Lesieur Z, Vanhems P, Amour S, L'Honneur AS, Fidouh N, Foulongne V, Lagathu G, Duval X, Merle C, Lina B, Carrat F, Launay O, Loubet P. In-hospital and midterm out-hospital complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study. Eur Respir J. 2021 Aug 26; doi: 10.1183/13993003.00651-2021. Epub 2021 Aug 26. PMID: 34446468.
Copy Download .nbib Format: NLM
Share it on

Eur Respir J. 2021 Aug 26; doi: 10.1183/13993003.00651-2021. Epub 2021 Aug 26.

In-hospital and midterm out-hospital complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019: an observational study.

The European respiratory journal

Alexandre Descamps, Nezha Lenzi, Florence Galtier, Fabrice Lainé, Zineb Lesieur, Philippe Vanhems, Sélilah Amour, Anne-Sophie L'Honneur, Nadhira Fidouh, Vincent Foulongne, Gisèle Lagathu, Xavier Duval, Corinne Merle, Bruno Lina, Fabrice Carrat, Odile Launay, Paul Loubet,

Affiliations

  1. Université de Paris, Inserm CIC 1417, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, CIC Cochin Pasteur, Paris, France.
  2. Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France.
  3. Inserm CIC 1411, Montpellier University Hospital, Montpellier, France.
  4. Inserm CIC 1414, CHU Rennes, Rennes, France.
  5. Service Hygiène, Épidémiologie, Infection, Vigilance et Prévention (SHEIP), Hôpital Édouard Herriot, Hospices Civils de Lyon, Lyon, France.
  6. Centre International de Recherche en Infectiologie (CIRI), Equipe Public Health Epidemiology and Evolutionary Ecology of Infectious Diseases (PHE3ID), Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
  7. Service de Virologie, Hôpital Cochin, Paris, France.
  8. Laboratoire de Virologie, Hôpital Bichat, Paris, France.
  9. Service de Virologie, CHU Montpellier, Hôpital Saint Eloi, Montpellier, France.
  10. Laboratoire de virologie, Pôle micro-organismes, CHU Rennes, Rennes, France.
  11. Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, Paris, France.
  12. Université de Paris, IAME, INSERM, Paris, France.
  13. Infectious Diseases Department, Montpellier University Hospital, Montpellier, France.
  14. Hospices Civils de Lyon, Laboratoire de Virologie, Institut des Agents Infectieux (IAI), Centre National de Référence des virus Respiratoires France Sud, Hôpital de la Croix-Rousse, Lyon, France.
  15. Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Assistance Publique Hôpitaux de Paris, Hôpital Saint Antoine, Paris, France.
  16. Last authors contributed equally to this article.
  17. Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France [email protected].
  18. Department of Infectious and Tropical Disease, VBMI, INSERM U1047, CHU Nîmes, Univ Montpellier, Nîmes, France.

PMID: 34446468 DOI: 10.1183/13993003.00651-2021

Abstract

OBJECTIVES: To describe the clinical characteristics and in/out-hospital outcomes of respiratory syncytial virus (RSV) infection among adults hospitalised with influenza-like illness (ILI) and compared against patients admitted for influenza.

METHODS: Adults hospitalised with ILI were prospectively included from five French university hospitals over two consecutive winter seasons (2017/2018 and 2018/2019). RSV and influenza virus were detected by multiplex RT-PCR on nasopharyngeal swabs. RSV-positive patients were compared to RSV-negative and influenza-positive hospitalised patients. Poisson regression models were used to estimate the adjusted prevalence ratio (aPR) associated with in-hospital and post-discharge outcomes between RSV and influenza infections. The in-hospital outcome was a composite of the occurrence of at least one complication, length of stay ≥7 days, intensive care unit (ICU) admission, use of mechanical ventilation and in-hospital death. Post-discharge outcome included 30/90-day all-cause mortality and 90-day readmission rates.

RESULTS: Overall, 1,428 hospitalised adults with ILI were included. RSV was detected in 8% (114/1428) and influenza virus in 31% (437/1428). Patients hospitalised with RSV were older than those with influenza (mean age, 73.0

CONCLUSION: RSV infection results in serious respiratory illness with in-hospital outcomes worse than influenza and with similar midterm post-discharge outcomes.

Copyright ©The authors 2021. For reproduction rights and permissions contact [email protected].

Publication Types